{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:03:55Z","timestamp":1784934235834,"version":"3.55.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Ceftriaxone-resistant (CRO-R) Escherichia coli bloodstream infections (BSIs) are common.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a prospective cohort of patients with E coli BSI at 14 United States hospitals between November 2020 and April 2021. For each patient with a CRO-R E coli BSI enrolled, the next consecutive patient with a ceftriaxone-susceptible (CRO-S) E coli BSI was included. Primary outcome was desirability of outcome ranking (DOOR) at day 30, with 50% probability of worse outcomes in the CRO-R group as the null hypothesis. Inverse probability weighting (IPW) was used to reduce confounding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Notable differences between patients infected with CRO-R and CRO-S E coli BSI included the proportion with Pitt bacteremia score \u22654 (23% vs 15%, P = .079) and the median time to active antibiotic therapy (12\u2005hours [interquartile range {IQR}, 1\u201335 hours] vs 1\u2005hour [IQR, 0\u20136 hours]; P &amp;lt; .001). Unadjusted DOOR analyses indicated a 58% probability (95% confidence interval [CI], 52%\u201363%) for a worse clinical outcome in CRO-R versus CRO-S BSI. In the IPW-adjusted cohort, no difference was observed (54% [95% CI, 47%\u201361%]). Secondary outcomes included unadjusted and adjusted differences in the proportion of 30-day mortality between CRO-R and CRO-S BSIs (\u22125.3% [95% CI, \u221210.3% to \u2212.4%] and \u22121.8 [95% CI, \u22126.7% to 3.2%], respectively), postculture median length of stay (8 days [IQR, 5\u201313 days] vs 6 days [IQR, 4\u20139 days]; P &amp;lt; .001), and incident admission to a long-term care facility (22% vs 12%, P = .045).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with CRO-R E coli BSI generally have poorer outcomes compared to patients infected with CRO-S E coli BSI, even after adjusting for important confounders.<\/jats:p>\n               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