{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:10:57Z","timestamp":1753877457880,"version":"3.41.2"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:00:00Z","timestamp":1667433600000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Studies on the pulmonary consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are impeded by limited access to pre\u2013SARS-CoV-2 examinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We invited Copenhagen General Population Study participants with a confirmed SARS-CoV-2 polymerase chain reaction (PCR) test during the first and second coronavirus disease 2019 waves in Denmark for a repeat chest computed tomography (CT) scan. Paired CT scans were independently assessed for interstitial and noninterstitial abnormalities by 2 trained radiologists. A semiquantitative CT score (ranging from 0 to 20) was used to quantify the extent of interstitial abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 111 SARS-CoV-2\u2013infected individuals, 102 (91.2%) experienced symptoms and 12 (11.2%) were hospitalized. Follow-up examination was performed at median of 5.4 (interquartile range, 4.1\u20137.8) months after a positive SARS-CoV-2 PCR test. Of 67 individuals with paired CT scans, ground glass opacities and reticulation were present in 31 (46.3%) individuals post\u2013SARS-CoV-2 compared to 23 (34.1%) pre\u2013SARS-CoV-2 (mean CT score, 3.0 vs 1.3; P = .011). Results were similar for nonhospitalized individuals. We did not detect development of bronchiectasis, emphysema, or nodules.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>SARS-CoV-2 infection in predominantly nonhospitalized individuals with mild disease was associated with a small increase in only interstitial lung abnormalities.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac596","type":"journal-article","created":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T20:08:35Z","timestamp":1667506115000},"source":"Crossref","is-referenced-by-count":1,"title":["Lung Abnormalities in Severe Acute Respiratory Syndrome Coronavirus 2 Infection: An Analysis of Paired Computed Tomography Scans Before and After Infection"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-8954","authenticated-orcid":false,"given":"Katrine K","family":"Iversen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases 144, Copenhagen University Hospital\u2013Amager Hvidovre , Hvidovre , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-7524","authenticated-orcid":false,"given":"Andreas","family":"Ronit","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases 144, Copenhagen University Hospital\u2013Amager Hvidovre , Hvidovre , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7305-0880","authenticated-orcid":false,"given":"Thomas S","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Department of Radiology and Cardiology, Copenhagen University Hospital\u2013Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-4694","authenticated-orcid":false,"given":"Shoaib","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2013Herlev and Gentofte , Herlev , Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"The Copenhagen General Population Study, Copenhagen University Hospital\u2013Herlev and Gentofte , Herlev , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Jankovic","sequence":"additional","affiliation":[{"name":"Department of Radiology and Cardiology, Copenhagen University Hospital\u2013Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-7896","authenticated-orcid":false,"given":"Anna","family":"Kalhauge","sequence":"additional","affiliation":[{"name":"Department of Radiology and Cardiology, Copenhagen University Hospital\u2013Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5546-3959","authenticated-orcid":false,"given":"Magnus G","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital\u2013Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-7220","authenticated-orcid":false,"given":"B\u00f8rge G","family":"Nordestgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Copenhagen University Hospital\u2013Herlev and Gentofte , Herlev , Denmark"},{"name":"Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark"},{"name":"The Copenhagen General Population Study, Copenhagen University Hospital\u2013Herlev and Gentofte , Herlev , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-1554","authenticated-orcid":false,"given":"Klaus F","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Department of Radiology and Cardiology, Copenhagen University Hospital\u2013Rigshospitalet , Copenhagen , Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0698-9385","authenticated-orcid":false,"given":"Thomas","family":"Benfield","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases 144, Copenhagen University Hospital\u2013Amager Hvidovre , Hvidovre , 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