{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:33:25Z","timestamp":1792794805680,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pulmonary Vascular Research Institute","award":["422348"],"award-info":[{"award-number":["422348"]}],"id":[{"id":"https:\/\/ror.org\/02ca75c45","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000801","name":"Bayer Healthcare","doi-asserted-by":"crossref","award":["411278"],"award-info":[{"award-number":["411278"]}],"id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hatter Institute for Cardiovascular Research in Africa","id":[{"id":"https:\/\/ror.org\/05c9qnd49","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007112","name":"University of Cape Town","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007112","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Data characterizing risk factors and long-term outcome studies on human immunodeficiency virus (HIV)-associated pulmonary hypertension (PH) in Africa are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The Pan African Pulmonary Hypertension Cohort, a multinational registry of 254 consecutive patients diagnosed with PH (97% of African descent) from 9 centers in 4 African countries was implemented. We compared baseline characteristics and 3-year survival of an HIV-infected cohort newly diagnosed with PH (PH\/HIV+) to an HIV-uninfected cohort with PH (PH\/HIV\u2212).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred thirty-four participants with PH completed follow up (47 PH\/HIV+ and 87 PH\/HIV\u2212; age median, 36 versus 44\u2005years; P = .0004). Cardiovascular risk factors and comorbidities were similar except for previous tuberculosis (62% versus 18%, P &amp;lt; .0001). Six-minute walk distance (6MWD) &amp;lt;300 meters was common in PH\/HIV\u2212 (P = .0030), but PH\/HIV+ had higher heart (P = .0160) and respiratory (P = .0374) rates. Thirty-six percent of PH\/HIV+ and 15% of PH\/HIV\u2212 presented with pulmonary arterial hypertension (PAH) (P = .0084), whereas 36% of PH\/HIV+ and 72% of PH\/HIV\u2212 exhibited PH due to left heart disease (PHLHD) (P = .0009). Pulmonary hypertension due to lung diseases and hypoxia (PHLD) was frequent in PH\/HIV+ (36% versus 15%) but did not reach statistical significance. Human immunodeficiency virus-associated PAH tended to have a poorer survival rate compared with PHLHD\/PHLD in HIV-infected patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PH\/HIV + patients were younger and commonly had previous tuberculosis compared to PH\/HIV\u2212 patients. Despite a better 6MWD at presentation, they had more signs and symptoms of early onset heart failure and a worse survival rate. Early echocardiography assessment should be performed in HIV-infected patients with history of tuberculosis who present with signs and symptoms of heart failure or posttuberculosis lung disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofac604","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T04:00:10Z","timestamp":1669608010000},"source":"Crossref","is-referenced-by-count":13,"title":["Long-Term Follow-up of Human Immunodeficiency Virus-Associated Pulmonary Hypertension: Clinical Features and Survival Outcomes of the Pan Africa Pulmonary Hypertension Cohort (PAPUCO)"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4801-2030","authenticated-orcid":false,"given":"Friedrich","family":"Thienemann","sequence":"first","affiliation":[{"name":"General Medicine & Global Health, Cape Heart Institute, Faculty of Health Science, University of Cape Town , Cape Town , South Africa"},{"name":"Department of Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa"},{"name":"Department of Internal Medicine, University Hospital Zurich, University of Zurich , Zurich , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D M C","family":"Katoto","sequence":"additional","affiliation":[{"name":"General Medicine & Global Health, Cape Heart Institute, Faculty of Health Science, University of Cape Town , Cape Town , South Africa"},{"name":"Department of Medicine and Center for Infectious Diseases, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town , South Africa"},{"name":"Department of Medicine, Division of Respiratory Medicine and Prof. Lurhuma Biomedical Research Laboratory, Mycobacterium Unit, Catholic University of Bukavu , Bukavu , Democratic Republic of Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feriel","family":"Azibani","sequence":"additional","affiliation":[{"name":"General Medicine & Global Health, Cape Heart Institute, Faculty of Health Science, University of Cape Town , Cape Town , South Africa"},{"name":"INSERM U942 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaris","family":"Kodogo","sequence":"additional","affiliation":[{"name":"General Medicine & Global Health, Cape Heart Institute, Faculty of Health Science, University of Cape Town , Cape Town , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L","family":"Mukasa","sequence":"additional","affiliation":[{"name":"General Medicine & Global Health, Cape Heart Institute, Faculty of Health Science, University of Cape Town , Cape Town , South Africa"},{"name":"Department of Medicine, Faculty of Health Sciences, University of Cape Town , Cape Town , South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud U","family":"Sani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University Kano and Aminu Kano Teaching Hospital , Kano , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamilu M","family":"Karaye","sequence":"additional","affiliation":[{"name":"Department of Medicine, Bayero University Kano and Aminu Kano Teaching Hospital , Kano , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Mbanze","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Eduardo Mondlane , Maputo , Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana O","family":"Mocumbi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Eduardo Mondlane , Maputo , Mozambique"},{"name":"Instituto Nacional de Sa\u00fade , Maputo , 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