{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:23:31Z","timestamp":1778048611222,"version":"3.51.4"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Mycoplasma hominis, Ureaplasma urealyticum, and Ureaplasma parvum may cause post-transplant infections in lung transplant recipients. We evaluated routine pretransplant screening for these Mollicutes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively reviewed records of lung transplant recipients at our tri-site institution from 01\/01\/2015 to 11\/15\/2019. M. hominis and\/or Ureaplasma polymerase chain reaction (PCR) was performed on pretransplant recipient urine specimens and donor bronchial swabs at the time of transplantation. Development of Mollicute infection and hyperammonemia syndrome (HS) was recorded.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 268 patients underwent lung transplantation during the study period, of whom 105 were screened with at least 1 Mollicute PCR. Twelve (11%) screened positive; 10 donors, 1 recipient, and 1 both. Among positive donors, 3 were positive for M. hominis, 5 for U. urealyticum, and 4 for U. parvum. Preemptive therapy included doxycycline, levofloxacin, and\/or azithromycin administered for 1\u201312 weeks. Despite therapy, 1 case of M. hominis mediastinitis and 1 case of HS associated with Ureaplasma infection occurred, both donor-derived. Of those screened before transplant, cases with positive screening were more likely (P &amp;lt; 0.05) to develop Mollicute infection despite treatment (2\/12, 17%) than those who screened negative (1\/93, 1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Pretransplant recipient urine screening had a low yield and was not correlated with post-transplant Mollicute infection, likely because most M. hominis and U. parvum\/urealyticum infections in lung transplant recipients are donor-derived. Routine donor bronchus swab PCR for M. hominis, U. urealyticum, and U. parvum followed by preemptive therapy did not obviously impact the overall incidence of Mollicute infection or HS in this cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofac607","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T09:00:30Z","timestamp":1667811630000},"source":"Crossref","is-referenced-by-count":13,"title":["Routine Donor and Recipient Screening for <i>Mycoplasma hominis<\/i> and <i>Ureaplasma<\/i> Species in Lung Transplant Recipients"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7143-6886","authenticated-orcid":false,"given":"Prakhar","family":"Vijayvargiya","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"},{"name":"Division of Infectious Diseases, Department of Medicine, University of Mississippi Medical Center , Jackson, Mississippi , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zerelda","family":"Esquer Garrigos","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"},{"name":"Division of Infectious Diseases, Department of Medicine, University of Mississippi Medical Center , Jackson, Mississippi , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie C","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C","family":"Daly","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Department of Surgery, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"Wylam","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6344-4141","authenticated-orcid":false,"given":"Robin","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"},{"name":"Division of Clinical Microbiology, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-2299","authenticated-orcid":false,"given":"Elena","family":"Beam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Mayo Clinic College of Medicine and Science , Rochester, Minnesota , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"2022113009501738700_ofac607-B1","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1111\/ajt.16394","article-title":"Association between Mycoplasma and Ureaplasma airway positivity, ammonia levels, and outcomes post-lung transplantation: a prospective surveillance study","volume":"21","author":"Buzo","year":"2020","journal-title":"Am J Transplant"},{"key":"2022113009501738700_ofac607-B2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa8419","article-title":"Disseminated Ureaplasma infection as a cause of fatal hyperammonemia in humans","volume":"7","author":"Bharat","year":"2015","journal-title":"Sci Transl Med"},{"key":"2022113009501738700_ofac607-B3","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1093\/cid\/cix601","article-title":"Donor-derived Mycoplasma hominis and an apparent cluster of M. hominis cases in solid organ transplant recipients","volume":"65","author":"Smibert","year":"2017","journal-title":"Clin Infect Dis"},{"key":"2022113009501738700_ofac607-B4","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.12957","article-title":"Idiopathic hyperammonemia after solid organ transplantation: primarily a lung problem? A single-center experience and systematic review","volume":"31","author":"Krutsinger","year":"2017","journal-title":"Clin Transplant"},{"key":"2022113009501738700_ofac607-B5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.healun.2017.04.009","article-title":"Donor-derived Ureaplasma is a potentially lethal infection in lung allograft recipients","volume":"36","author":"Bharat","year":"2017","journal-title":"J Heart Lung Transplant"},{"key":"2022113009501738700_ofac607-B6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1399-3062.2009.00457.x","article-title":"Mycoplasma hominis pericarditis in a lung transplant recipient: review of the literature about an uncommon but important cardiothoracic pathogen","volume":"12","author":"Mitsani","year":"2010","journal-title":"Transpl Infect Dis"},{"key":"2022113009501738700_ofac607-B7","doi-asserted-by":"crossref","first-page":"e13822","DOI":"10.1111\/tid.13822","article-title":"Mycoplasma hominis infections 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