{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:41:29Z","timestamp":1792010489578,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005205","name":"Janssen Research & Development","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive Escherichia coli disease (IED), including bloodstream infection, sepsis, and septic shock, can lead to high hospitalization and mortality rates. This multinational study describes the clinical profile of patients with IED in tertiary care hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We applied clinical criteria of systemic inflammatory response syndrome (SIRS), sepsis, or septic shock to patients hospitalized with culture-confirmed E coli from urine or a presumed sterile site. We assessed a proposed clinical case definition against physician diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most patients with IED (N = 902) were adults aged \u226560\u2005years (76.5%); 51.9%, 25.1%, and 23.0% of cases were community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA), respectively. The urinary tract was the most common source of infection (52.3%). Systemic inflammatory response syndrome, sepsis, and septic shock were identified in 77.4%, 65.3%, and 14.1% of patients, respectively. Patients &amp;gt;60\u2005years were more likely to exhibit organ dysfunction than those \u226460\u2005years; this trend was not observed for SIRS. The case-fatality rate (CFR) was 20.0% (60\u201375\u2005years, 21.5%; \u226575\u2005years, 22.2%), with an increase across IED acquisition settings (HA, 28.3%; HCA, 21.7%; CA, 15.2%). Noticeably, 77.8% of patients initiated antibiotic use on the day of culture sample collection. A total of 65.6% and 40.8% of E coli isolates were resistant to \u22651 agent in \u22651 or \u22652 drug class(es). A 96.1% agreement was seen between the proposed clinical case definition and physician's diagnoses of IED.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study contributes valuable, real-world data about IED severity. An accepted case definition could promote timely and accurate diagnosis of IED and inform the development of novel preventative strategies.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofad026","type":"journal-article","created":{"date-parts":[[2023,1,28]],"date-time":"2023-01-28T08:35:13Z","timestamp":1674894913000},"source":"Crossref","is-referenced-by-count":33,"title":["Epidemiology, Clinical Features, and Antimicrobial Resistance of Invasive<i>Escherichia Coli<\/i>Disease in Patients Admitted in Tertiary Care Hospitals"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3503-3596","authenticated-orcid":false,"given":"Joachim","family":"Doua","sequence":"first","affiliation":[{"name":"Janssen Research & Development, Infectious Diseases & Vaccines, Janssen Pharmaceutica , Beerse , Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Geurtsen","sequence":"additional","affiliation":[{"name":"Bacterial Vaccines 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