{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:53:59Z","timestamp":1787162039291,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Management of Scedosporium\/Lomentospora prolificans infections remains challenging. We described predisposing factors, clinical manifestations, and outcomes of these rare mold infections, including predictors of early (1-month) and late (18-month) all-cause mortality and treatment failure.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We conducted a retrospective Australian-based observational study of proven\/probable Scedosporium\/L prolificans infections from 2005 to 2021. Data on patient comorbidities, predisposing factors, clinical manifestations, treatment, and outcomes up to 18 months were collected. Treatment responses and death causality were adjudicated. Subgroup analyses, multivariable Cox regression, and logistic regression were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 61 infection episodes, 37 (60.7%) were attributable to L prolificans. Forty-five of 61 (73.8%) were proven invasive fungal diseases (IFDs), and 29 of 61 (47.5%) were disseminated. Prolonged neutropenia and receipt of immunosuppressant agents were documented in 27 of 61 (44.3%) and 49 of 61 (80.3%) episodes, respectively. Voriconazole\/terbinafine was administered in 30 of 31 (96.8%) L prolificans infections, and voriconazole alone was prescribed for 15 of 24 (62.5%) Scedosporium spp infections. Adjunctive surgery was performed in 27 of 61 (44.3%) episodes. Median time to death post\u2013IFD diagnosis was 9.0 days, and only 22 of 61 (36.1%) attained treatment success at 18 months. Those who survived beyond 28 days of antifungal therapy were less immunosuppressed with fewer disseminated infections (both P &lt; .001). Disseminated infection and hematopoietic stem cell transplant were associated with increased early and late mortality rates. Adjunctive surgery was associated with lower early and late mortality rates by 84.0% and 72.0%, respectively, and decreased odds of 1-month treatment failure by 87.0%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Outcomes associated with Scedosporium\/L prolificans infections is poor, particularly with L prolificans infections or in the highly immunosuppressed population.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/ofid\/ofad059","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T04:21:58Z","timestamp":1675830118000},"source":"Crossref","is-referenced-by-count":37,"title":["Invasive\n Scedosporium<\/i>\n and\n Lomentospora prolificans<\/i>\n Infections in Australia: A Multicenter Retrospective Cohort Study"],"prefix":"10.1093","volume":"10","author":[{"given":"Chin Fen","family":"Neoh","sequence":"first","affiliation":[{"name":"National Centre for Infections in Cancer, Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon C A","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology, Westmead Hospital , Sydney , Australia"},{"name":"Faculty of Health Sciences, Sydney Medical School, University of Sydney , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Crowe","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, St Vincent's Hospital Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology Laboratory Services, New South Wales Health Pathology, Westmead Hospital , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc A","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital Sydney , Sydney , Australia"},{"name":"Kolling Institute, Faculty of Medicine and Health, University of Sydney and Northern Sydney Local Health District , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Marriott","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, St Vincent's Hospital Sydney , Sydney , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A","family":"Trubiano","sequence":"additional","affiliation":[{"name":"National Centre for Infections in Cancer, Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne , Melbourne , Australia"},{"name":"Department of Infectious Diseases, Austin Hospital , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Spelman","sequence":"additional","affiliation":[{"name":"Department of Health Services Research, Peter MacCallum Cancer Centre , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-9060","authenticated-orcid":false,"given":"David C M","family":"Kong","sequence":"additional","affiliation":[{"name":"National Centre for Antimicrobial Stewardship, Peter Doherty Institute for Infections and Immunity , Melbourne , Australia"},{"name":"Centre for Medicine Use and Safety, Monash Institute of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University , Melbourne , Australia"},{"name":"Pharmacy Department, Grampians Health\u2013Ballarat , Melbourne , Australia"},{"name":"School of Medicine, Deakin University , Geelong , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-314X","authenticated-orcid":false,"given":"Monica A","family":"Slavin","sequence":"additional","affiliation":[{"name":"National Centre for Infections in Cancer, Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Department of Infectious Diseases, Peter MacCallum Cancer Centre , Melbourne , Australia"},{"name":"Sir Peter MacCallum Department of Oncology, University of Melbourne , Melbourne , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,8]]},"reference":[{"issue":"Suppl 1","key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.1093\/mmy\/myx113","article-title":"Scedosporium and Lomentospora: an updated overview of underrated opportunists","volume":"56","author":"Ramirez-Garcia","year":"2018","journal-title":"Med Mycol"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/AAC.05910-11","article-title":"Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species","volume":"56","author":"Lackner","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1093\/jac\/dks210","article-title":"Hospital costs, length of stay and mortality attributable to invasive scedosporiosis in haematology patients","volume":"67","author":"Heng","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"2023022716334319300_","first-page":"1050","article-title":"In vitro activity of the novel antifungal compound F901318 against Australian Scedosporium and Lomentospora fungi","volume":"56","author":"Biswas","year":"2018","journal-title":"Med Mycol"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"e0043421","DOI":"10.1128\/AAC.00434-21","article-title":"In vivo efficacy of olorofim against systemic scedosporiosis and lomentosporiosis","volume":"65","author":"Seyedmousavi","year":"2021","journal-title":"Antimicrob Agents Chemother"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"e01735-19","DOI":"10.1128\/AAC.01735-19","article-title":"Fosmanogepix (APX001) is effective in the treatment of immunocompromised mice infected with invasive pulmonary scedosporiosis or disseminated fusariosis","volume":"64","author":"Alkhazraji","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/jac\/dkz022","article-title":"In vitro activity of APX001A against rare moulds using EUCAST and CLSI methodologies","volume":"74","author":"Rivero-Menendez","year":"2019","journal-title":"J Antimicrob 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the diagnosis of invasive disease","volume":"7","author":"Chen","year":"2021","journal-title":"J Fungi (Basel)"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","article-title":"Revision and update of the consensus definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium","volume":"71","author":"Donnelly","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2023022716334319300_","doi-asserted-by":"crossref","first-page":"490.e1\u201310","DOI":"10.1016\/j.cmi.2014.12.021","article-title":"Invasive infections due to filamentous fungi other than Aspergillus: epidemiology and determinants of mortality","volume":"21","author":"Slavin","year":"2015","journal-title":"Clin Microbiol 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