{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:18:26Z","timestamp":1779211106523,"version":"3.51.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T00:00:00Z","timestamp":1676678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer AG","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["438122637"],"award-info":[{"award-number":["438122637"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["P6\/KFO 306"],"award-info":[{"award-number":["P6\/KFO 306"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Coagulopathy is common in acute symptomatic Plasmodium falciparum malaria, and the degree of coagulation abnormality correlates with parasitemia and disease severity. Chronic asymptomatic malaria has been associated with increased morbidity. However, the role of coagulation activation in asymptomatic, semi-immune individuals remains unclear. This study investigates the potential effect of asymptomatic P falciparum infection on coagulation activation in semi-immune Ghanaian adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood from asymptomatic Ghanaian adults with P falciparum blood stage infection detectable by polymerase chain reaction (PCR) or by both PCR and rapid diagnostic test and from noninfected individuals, was investigated. Markers of coagulation activation including global coagulation tests, D-dimer, antithrombin III, fibrinogen, and von Willebrand factor antigen were tested. Furthermore, blood count, inflammation markers, and liver and kidney function tests were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Acquired coagulopathy was not found in asymptomatic P falciparum infection. Asymptomatic malaria was associated with significantly lower platelet counts. Systemic inflammation markers and liver and kidney function tests were not altered compared to noninfected controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is no laboratory evidence for acquired coagulopathy in adults with asymptomatic P falciparum malaria in highly endemic regions. Lack of laboratory evidence for systemic inflammation and liver and kidney dysfunction indicates that asymptomatic malaria may not be associated with significant morbidity.<\/jats:p><\/jats:sec>","DOI":"10.1093\/ofid\/ofad074","type":"journal-article","created":{"date-parts":[[2023,2,18]],"date-time":"2023-02-18T19:53:33Z","timestamp":1676750013000},"source":"Crossref","is-referenced-by-count":4,"title":["Absence of Malaria-Associated Coagulopathy in Asymptomatic<i>Plasmodium falciparum<\/i>Infection: Results From a Cross-sectional Study in the Ashanti Region, Ghana"],"prefix":"10.1093","volume":"10","author":[{"given":"Christina Charlotte","family":"Rolling","sequence":"first","affiliation":[{"name":"Department of Oncology and Hematology, Bone Marrow Transplantation with section of Pneumology, Hubertus Wald Tumorzentrum\u2013University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O","family":"Phillips","sequence":"additional","affiliation":[{"name":"Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology , Kumasi , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kabiru Mohammed","family":"Abass","sequence":"additional","affiliation":[{"name":"Presbyterian Hospital , Agogo , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ken Adu Poku","sequence":"additional","affiliation":[{"name":"Presbyterian Hospital , Agogo , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Osei-Mireku","sequence":"additional","affiliation":[{"name":"Presbyterian Hospital , Agogo , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bright","family":"Osei-Wusu","sequence":"additional","affiliation":[{"name":"Presbyterian Hospital , Agogo , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Thompson","sequence":"additional","affiliation":[{"name":"Presbyterian Hospital , Agogo , Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof D","family":"Vinnemeier","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"},{"name":"German Centre for Infection Research, Hamburg-L\u00fcbeck-Borstel-Riems Site , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Huebl","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine and I. Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Langer","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, Bone Marrow Transplantation with section of Pneumology, Hubertus Wald Tumorzentrum\u2013University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Francke","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Kuta","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Konrath","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Renn\u00e9","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany"},{"name":"Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland , Dublin , Ireland"},{"name":"Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center , Mainz , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egbert","family":"Tannich","sequence":"additional","affiliation":[{"name":"National Reference Centre for Tropical Pathogens, Bernhard Nocht Institute for Tropical Medicine , Hamburg , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Rolling","sequence":"additional","affiliation":[{"name":"German Centre for Infection Research, Hamburg-L\u00fcbeck-Borstel-Riems Site , Germany"},{"name":"Division of Infectious Diseases, I. 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