{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:52:39Z","timestamp":1792097559726,"version":"4.4.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"German Centre for Infection Research","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Faculty Heidelberg, Germany,"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Viral acute respiratory tract infections (ARTIs) are a leading cause of hospitalization in infants and young children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During the winter seasons of 2014\u20132018, hospitalized children (&amp;lt;18 years) with symptoms of ARTI were prospectively included at the University Hospital Heidelberg, Germany. Nasopharyngeal swabs were obtained for multiplex molecular analysis of 10 groups of respiratory viruses, and clinical data were obtained using a standardized questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1353 children included in this study, 1142 (84.4%) were positive for \u22651 viral pathogen. Virus monoinfection was detected in 797 (69.8%) children, whereas 345 (30.2%) children had coinfections with 2\u20134 viral pathogens. Respiratory syncytial virus (RSV), rhinovirus, and influenza virus were the main pathogens detected. RSV-positive children had significantly more often lower ARTIs, including symptoms of severe cough, wheezing, chest indrawing, tachypnea, and pulmonary rales. Hospitalized children aged &amp;lt;6 months represented the largest age group with detection of \u22651 viral pathogen (455\/528 [86.2%] children). Coinfection was more frequent in younger children and, particularly for RSV with rhinovirus, significantly associated with more severe respiratory symptoms (P = .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A better understanding of the etiology of viral ARTIs among hospitalized children plays a key role for future strategies in prevention, control, and treatment of respiratory viral infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofad110","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T14:20:48Z","timestamp":1677680448000},"source":"Crossref","is-referenced-by-count":31,"title":["Viral Etiology and Clinical Characteristics of Acute Respiratory Tract Infections in Hospitalized Children in Southern Germany (2014\u20132018)"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-9464","authenticated-orcid":false,"given":"Julia","family":"Tabatabai","sequence":"first","affiliation":[{"name":"Virology, Center for Infectious Diseases, University of Heidelberg , Heidelberg , Germany"},{"name":"German Center for Infectious Diseases , Heidelberg , Germany"},{"name":"Center for Child and Adolescent Medicine, University Hospital Heidelberg , Heidelberg , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara M","family":"Ihling","sequence":"additional","affiliation":[{"name":"German Center for Infectious Diseases , Heidelberg , Germany"},{"name":"Dr von Haunersches Kinderspital, University Hospital of the Ludwig-Maximilians-University Munich , Munich , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Manuel","sequence":"additional","affiliation":[{"name":"Virology, Center for Infectious Diseases, 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