{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:27:42Z","timestamp":1773268062502,"version":"3.50.1"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing parechovirus (PeV) infections prompted a Centers for Disease Control and Prevention Health Advisory in July 2022. We retrospectively assessed national PeV trends in cerebrospinal fluid and observed unexpected viral dynamics from 2020 to 2022 with regional variance. These findings may be due to mitigation strategies aimed at severe acute respiratory syndrome coronavirus 2. PeV testing can benefit ill patients, particularly children.<\/jats:p>","DOI":"10.1093\/ofid\/ofad112","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T13:15:49Z","timestamp":1677762949000},"source":"Crossref","is-referenced-by-count":12,"title":["Re-emergence of<i>Parechovirus<\/i>: 2017\u20132022 National Trends of Detection in Cerebrospinal Fluid"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3911","authenticated-orcid":false,"given":"Lili","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-156X","authenticated-orcid":false,"given":"Romney M","family":"Humphries","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7320-5635","authenticated-orcid":false,"given":"David C","family":"Gaston","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/S1473-3099(18)30288-3","article-title":"Strategies to improve detection and management of human Parechovirus infection in young infants","volume":"19","author":"Kadambari","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.3390\/v11111062","article-title":"Parechovirus A pathogenesis and the enigma of genotype A-3","volume":"11","author":"Sridhar","year":"2019","journal-title":"Viruses"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jmv.26395","article-title":"Human Parechovirus are emerging pathogens with broad spectrum of clinical syndromes in adults","volume":"92","author":"Kabuga","year":"2020","journal-title":"J Med Virol"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/INF.0000000000001718","article-title":"Epidemiology of sepsis-like illness in young infants: major role of enterovirus and human Parechovirus","volume":"37","author":"de Jong","year":"2017","journal-title":"Pediatric Infect Dis J"},{"key":"2023032309281802200_","author":"Centers for Disease Control and Prevention"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"977","DOI":"10.15585\/mmwr.mm7130a5","article-title":"Notes from the field: cluster of Parechovirus central nervous system infections in young infants\u2014Tennessee, 2022","volume":"71","author":"Tao","year":"2022","journal-title":"MMWR Morbidity Mortal Wkly Rep"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"3078","DOI":"10.1073\/pnas.1721159115","article-title":"The seasonality of nonpolio enteroviruses in the United States: patterns and drivers","volume":"115","author":"Pons-Salort","year":"2018","journal-title":"Proc National Acad Sci U S A"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.02106-20","article-title":"Positive impact of routine testing for Enterovirus and Parechovirus on length of hospitalization and antimicrobial use among inpatients \u22646\u2005months of age","volume":"59","author":"Lee","year":"2020","journal-title":"J Clin Microbiol"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1080\/23744235.2017.1311417","article-title":"The BioFireFilmArray enables point of care diagnostic in neonatal Parechovirus meningitis","volume":"49","author":"L\u00f3pez","year":"2017","journal-title":"Infect Dis-Nor"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpeds.2019.12.026","article-title":"Early life Parechovirus infection neurodevelopmental outcomes at 3 years: a cohort study","volume":"219","author":"Britton","year":"2019","journal-title":"J Pediatrics"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/jpc.13728","article-title":"High prevalence of developmental concern amongst infants at 12 months following hospitalized Parechovirus infection","volume":"54","author":"Britton","year":"2016","journal-title":"J Paediatr Child H"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"e2083","DOI":"10.1002\/rmv.2083","article-title":"Outcomes beyond hospital discharge in infants and children with viral meningitis: a systematic review","volume":"30","author":"Hudson","year":"2020","journal-title":"Rev Med Virol"},{"key":"2023032309281802200_","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.3201\/eid2209.151497","article-title":"Nosocomial outbreak of Parechovirus 3 infection among newborns, Austria, 2014","volume":"22","author":"Strenger","year":"2016","journal-title":"Emerg Infect Dis"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofad112\/49394219\/ofad112.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/10\/3\/ofad112\/49601336\/ofad112.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/10\/3\/ofad112\/49601336\/ofad112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T05:20:16Z","timestamp":1679894416000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofad112\/7067160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3,3]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofad112","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2023,3,1]]},"article-number":"ofad112"}}