{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:24:48Z","timestamp":1788229488627,"version":"build-2803163510"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T00:00:00Z","timestamp":1679616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Institut Pasteur"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Eculizumab, a recombinant humanized monoclonal antibody (mAb), is used for the treatment of patients (both adults and children) with paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. This mAb binds to complement protein 5 (C5), thereby inhibiting its cleavage. On the other hand, one of the C5 cleavage products, C5a, is a potent anaphylatoxin with proinflammatory properties, involved in antimicrobial surveillance. Administration of eculizumab has been reported to make patients more susceptible to infection by encapsulated bacteria. Here, we are reporting an adult case of disseminated infection due to the encapsulated yeast Cryptococcus neoformans following eculizumab therapy and discuss its pathogenesis.<\/jats:p>","DOI":"10.1093\/ofid\/ofad159","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T17:36:47Z","timestamp":1679679407000},"source":"Crossref","is-referenced-by-count":12,"title":["Disseminated Cryptococcosis Following Eculizumab Therapy: Insight Into Pathogenesis"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8325-8060","authenticated-orcid":false,"given":"Olivier","family":"Lortholary","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Centre d'Infectiologie Necker-Pasteur, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris Cit\u00e9 , Paris , France"},{"name":"Institut Pasteur, Molecular Mycology Unit, Department of Mycology, Universit\u00e9 Paris Cit\u00e9 , Paris , France"},{"name":"Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"El-Sissy","sequence":"additional","affiliation":[{"name":"Inserm UMRS1138, Centre de Recherche des Cordeliers, Team \u201cInflammation, Complement and Cancer,\u201d Paris , France"},{"name":"Department of Immunology, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Leporrier","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, Centre d'Infectiologie Necker-Pasteur, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sze Wah Wong","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Molecular Mycology Unit, Department of Mycology, Universit\u00e9 Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Dannaoui","sequence":"additional","affiliation":[{"name":"Parasitology-Mycology Unit, Necker-Enfants Malades University Hospital, Assistance Publique-H\u00f4pitaux de Paris, Universit\u00e9 de Paris Cit\u00e9 , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Fremeaux-Bacchi","sequence":"additional","affiliation":[{"name":"Inserm UMRS1138, Centre de Recherche des Cordeliers, Team \u201cInflammation, Complement and Cancer,\u201d Paris , France"},{"name":"Department of Immunology, H\u00f4pital Europ\u00e9en Georges Pompidou, Assistance Publique-H\u00f4pitaux de Paris , Paris , 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