{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:19:59Z","timestamp":1792027199603,"version":"4.4.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017183","name":"Janssen Scientific Affairs, LLC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017183","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Literature describing respiratory syncytial virus (RSV)\u2013related complications in older adults in the United States is scarce. This study described risk factors of RSV-related complications and healthcare costs of Medicare-insured patients aged \u226560 years with medically attended RSV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>100% Medicare Research Identifiable Files (1 January 2007\u201331 December 2019) were used to identify adults aged \u226560 years with RSV (index: first diagnosis date). Predictors of \u22651 RSV-related complication (ie, pneumonia, acute respiratory failure, congestive heart failure, hypoxia\/dyspnea, non-RSV lower\/upper respiratory tract infections, or chronic respiratory disease) during the up to 6-month post\u2013RSV diagnosis period were identified. Patients with all aforementioned diagnoses during the 6 months pre-index could not be evaluated for a complication and were therefore ineligible for analyses. Differences between 6-month pre- and post-index total all-cause and respiratory\/infection-related healthcare costs were assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 175 392 patients with RSV were identified. Post\u2013RSV diagnosis, 47.9% had \u22651 RSV-related complication, with mean time-to-event of 1.0 month. The most common complications were pneumonia (24.0%), chronic respiratory disease (23.6%), and hypoxia or dyspnea (22.0%). Baseline predictors of \u22651 RSV-related complication included having previous diagnoses for complication\/comorbidity listed in the Methods, hypoxemia, chemotherapy, chest radiograph, stem cell transplant, and anti-asthmatic and bronchodilator use. Total all-cause and respiratory\/infection-related healthcare costs were $7797 and $8863 higher, respectively, post-index versus pre-index (both P &amp;lt; .001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this real-world study, almost half of patients with medically attended RSV experienced an RSV-related complication within 1 month post\u2013RSV diagnosis, and costs significantly increased post-diagnosis. Having a complication\/comorbidity pre-RSV predicted a higher risk of developing a different complication post\u2013RSV infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad203","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T11:58:41Z","timestamp":1681387121000},"source":"Crossref","is-referenced-by-count":16,"title":["Respiratory Syncytial Virus\u2013Related Complications and Healthcare Costs Among a Medicare-Insured Population in the United States"],"prefix":"10.1093","volume":"10","author":[{"given":"Jessica K","family":"DeMartino","sequence":"first","affiliation":[{"name":"Real World Value & Evidence, Janssen Scientific Affairs, LLC , Titusville, New Jersey , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Lafeuille","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Emond","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Rossi","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Wang","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Menlo Park, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Liu","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Menlo Park, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lefebvre","sequence":"additional","affiliation":[{"name":"Analysis Group, Inc , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girishanthy","family":"Krishnarajah","sequence":"additional","affiliation":[{"name":"Real World Value & Evidence, Janssen Scientific Affairs, LLC , Titusville, New Jersey , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"2023052003381371400_ofad203-B1","doi-asserted-by":"crossref","first-page":"l5021","DOI":"10.1136\/bmj.l5021","article-title":"Respiratory syncytial virus infection in adults","volume":"366","author":"Nam","year":"2019","journal-title":"BMJ"},{"key":"2023052003381371400_ofad203-B2","article-title":"Rates of medically attended RSV among US adults: a systematic review and meta-analysis","volume":"9","author":"McLaughlin","year":"2022","journal-title":"Open Forum Infect Dis"},{"key":"2023052003381371400_ofad203-B3","author":"Centers for Disease Control and Prevention"},{"key":"2023052003381371400_ofad203-B4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/s12913-018-3066-1","article-title":"Healthcare resource use and economic burden attributable to respiratory syncytial virus in the United States: a claims database analysis","volume":"18","author":"Amand","year":"2018","journal-title":"BMC Health Serv Res"},{"key":"2023052003381371400_ofad203-B5","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/infdis\/jiaa361","article-title":"Severe morbidity and short- and mid- to long-term mortality in older adults hospitalized with respiratory syncytial virus infection","volume":"222","author":"Tseng","year":"2020","journal-title":"J Infect Dis"},{"key":"2023052003381371400_ofad203-B6","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s12325-020-01230-3","article-title":"A real-world analysis of patient characteristics and predictors of hospitalization among US Medicare beneficiaries with respiratory syncytial virus infection","volume":"37","author":"Wyffels","year":"2020","journal-title":"Adv Ther"},{"key":"2023052003381371400_ofad203-B7","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1086\/605948","article-title":"Risk factors for respiratory failure associated with respiratory syncytial virus infection in adults","volume":"200","author":"Duncan","year":"2009","journal-title":"J Infect Dis"},{"key":"2023052003381371400_ofad203-B8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/irv.12751","article-title":"Prediction of serious RSV-related outcomes in older adults with outpatient RSV respiratory illness during 12 consecutive seasons","volume":"14","author":"Kieke","year":"2020","journal-title":"Influenza Other Respir Viruses"},{"key":"2023052003381371400_ofad203-B9","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1056\/NEJMp2216358","article-title":"The journey to RSV vaccines\u2014heralding an era of structure-based design","volume":"388","author":"Graham","year":"2023","journal-title":"N Engl J Med"},{"key":"2023052003381371400_ofad203-B10","author":"Sobi, Inc.","year":"2021"},{"key":"2023052003381371400_ofad203-B11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1056\/NEJMoa2110275","article-title":"Nirsevimab for prevention of RSV in healthy late-preterm and term infants","volume":"386","author":"Hammitt","year":"2022","journal-title":"N Engl J Med"},{"key":"2023052003381371400_ofad203-B12","year":"2019"},{"key":"2023052003381371400_ofad203-B13","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.13511","article-title":"RNA respiratory viral infections in solid organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice","volume":"33","author":"Manuel","year":"2019","journal-title":"Clin Transplant"},{"key":"2023052003381371400_ofad203-B14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1093\/cid\/cit471","article-title":"High morbidity and mortality in adults hospitalized for respiratory syncytial virus infections","volume":"57","author":"Lee","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2023052003381371400_ofad203-B15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/cid\/ciy991","article-title":"Severe morbidity and mortality associated with respiratory syncytial virus versus influenza infection in hospitalized older adults","volume":"69","author":"Ackerson","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2023052003381371400_ofad203-B16","author":"Bureau of Labor Statistics"},{"key":"2023052003381371400_ofad203-B17","doi-asserted-by":"crossref","first-page":"A790","DOI":"10.1016\/j.jval.2017.08.2321","article-title":"Evaluation of resource utilization among infants, young children and elderly patients diagnosed with 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