{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:20:37Z","timestamp":1783189237347,"version":"3.54.6"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Intramuscular long-acting antiretroviral drugs can improve adherence to lifelong antiretroviral treatment. Nevertheless, adipose tissue thickness and distribution play a critical role with injectable drugs. We describe a virological failure with cabotegravir and rilpivirine in a Black African woman with human immunodeficiency virus type 1 with gynoid fat distribution (ie, adipose tissue prevailing in the pelvis and hip area) and body mass index &amp;lt;30\u2005kg\/m2.<\/jats:p>","DOI":"10.1093\/ofid\/ofad217","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T09:14:56Z","timestamp":1683018896000},"source":"Crossref","is-referenced-by-count":9,"title":["Gynoid Fat Distribution and Adipocyte Trapping May Explain Virological Failure With Intramuscular Long-Acting Cabotegravir and Rilpivirine"],"prefix":"10.1093","volume":"10","author":[{"given":"Isabelle","family":"de Malliard","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Laure","family":"Houist","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-537X","authenticated-orcid":false,"given":"Gilles","family":"Peytavin","sequence":"additional","affiliation":[{"name":"Infection Antimicrobials Modelling Evolution, Inserm, Universit\u00e9 de Paris , Paris , France"},{"name":"Laboratoire de Pharmacologie-Toxicologie, Assistance Publique\u2013H\u00f4pitaux de Paris, H\u00f4pital Bichat Claude Bernard , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"L\u2019Yavanc","sequence":"additional","affiliation":[{"name":"Posthospitalization and Rehabilitation Unit, H\u00f4pital Jean Jaur\u00e9s , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Department of Virology, Henri Mondor Hospital , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Cappy","sequence":"additional","affiliation":[{"name":"Department of Virology, Henri Mondor Hospital , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Daniel","family":"Leli\u00e8vre","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"},{"name":"Vaccine Research Institut, Inserm U955 Equipe 16, Universit\u00e9 Paris Est Cr\u00e9teil , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Feredj","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vindrios","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Gallien","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Melica","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Infectious Diseases, Henri Mondor Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris , Cr\u00e9teil , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,2]]},"reference":[{"key":"2023052003451346300_ofad217-B1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/hiv.12878","article-title":"2019 update of the European AIDS Clinical Society guidelines for treatment of people living with HIV version 10.0","volume":"21","author":"Ryom","year":"2020","journal-title":"HIV Med"},{"key":"2023052003451346300_ofad217-B2","first-page":"1124","article-title":"Long-acting cabotegravir and rilpivirine after oral induction for HIV-1 infection","volume-title":"N Engl J 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