{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:40:15Z","timestamp":1793608815480,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007469","name":"Higher Education Research Promotion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012527","name":"Office of the Higher Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012527","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["NRU59-[014]-HR"],"award-info":[{"award-number":["NRU59-[014]-HR"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ratchadapiseksompotch Fund"},{"DOI":"10.13039\/100019603","name":"Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["RA59\/082"],"award-info":[{"award-number":["RA59\/082"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Elevated levels of high-sensitivity cardiac troponin (hs-cTn) are suggestive of myocardial cell injury and coronary artery disease. We explored the association between hs-cTn and subclinical arteriosclerosis using coronary artery calcification (CAC) scoring among 337 virally suppressed patients with human immunodeficiency virus (HIV) who were \u226550 years old and without evidence of known coronary artery disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Noncontrast cardiac computed tomography and blood sampling for hs-cTn, both subunit I (hs-cTnI) and subunit T (hs-cTnT), were performed. The relationship between CAC (Agatston score) and serum hs-cTn levels was analyzed using Spearman correlation and logistic regression models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The patients, of whom 62% were male, had a median age of 54 years and had been on antiretroviral therapy for a median of 16 years; the CAC score was &amp;gt;0 in 50% of patients and \u2265100 in 16%. Both hs-cTn concentrations were positively correlated with the Agatston score, with correlation coefficients of 0.28 and 0.27 (P &amp;lt; .001) for hs-cTnI and hs-cTnT, respectively. hs-cTnI and hs-cTnT concentrations of \u22654 and \u22655.3\u2005pg\/mL, respectively, provided the best performance for discriminating patients with Agatston scores \u2265100, with a sensitivity and specificity of 76% and 60%, respectively, for hs-cTnI and 70% and 50% for hs-cTnT. In multivariable logistic regression analysis, each log unit increase in hs-cTnI level was independently associated with increased odds of having an Agatston score \u2265100 (odds ratio, 2.83 [95% confidence interval, 1.69\u20134.75]; P &amp;lt;.001). Although not an independent predictor, hs-cTnT was also associated with an increased odds of having an Agatston score \u2265100 (odds ratio, 1.58 [95% confidence interval, .92\u20132.73]; P = .10).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among Asians aged \u226550 years with well-controlled HIV infection and without established cardiovascular disease, 50% had subclinical arteriosclerosis. Increasing hs-cTnI and hs-cTnT concentrations were associated with an increased risk of severe subclinical arteriosclerosis, and hs-cTn may be a potential biomarker to detect severe subclinical arteriosclerosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad234","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T10:15:59Z","timestamp":1683108959000},"source":"Crossref","is-referenced-by-count":8,"title":["High-Sensitivity Troponins and Subclinical Coronary Atherosclerosis Evaluated by Coronary Calcium Score Among Older Asians Living With Well-Controlled Human Immunodeficiency Virus"],"prefix":"10.1093","volume":"10","author":[{"given":"Pairoj","family":"Chattranukulchai","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, and Cardiac Center, King Chulalongkorn Memorial Hospital , Bangkok , 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