{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T06:22:11Z","timestamp":1778048531012,"version":"3.51.4"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperammonemia syndrome (HS) is a life-threatening condition occurring in solid organ transplant patients, affecting primarily lung recipients, and is associated with Mycoplasma hominis and\/or Ureaplasma spp infection. The organ donor was a young man who died of hypoxic brain injury and had urethral discharge antemortem. The donor and 4 solid organ transplant recipients had infection with M hominis and\/or Ureaplasma spp. The lung and heart recipients both developed altered conscious state and HS associated with M hominis and Ureaplasma spp infections. Despite treatment with antibiotics and ammonia scavengers, both the lung and heart recipients died at day +102 and day +254, respectively. After diagnosis in the thoracic recipients, screening samples from the liver recipient and 1 kidney recipient were culture positive for M hominis with or without Ureaplasma spp. Neither the liver nor kidney recipients developed HS. Our case series demonstrates the unique finding of M hominis and Ureaplasma spp dissemination from an immunocompetent donor across 4 different organ recipients. Phylogenetic whole genome sequencing analysis demonstrated that M hominis samples from recipients and donor were closely related, suggesting donor-derived infection. Screening of lung donors and\/or recipients for Mycoplasma and Ureaplasma spp is recommended, as well as prompt treatment with antimicrobials to prevent morbidity.<\/jats:p>","DOI":"10.1093\/ofid\/ofad263","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T22:04:40Z","timestamp":1684533880000},"source":"Crossref","is-referenced-by-count":15,"title":["<i>Mycoplasma<\/i> and <i>Ureaplasma<\/i> Donor-Derived Infection and Hyperammonemia Syndrome in 4 Solid Organ Transplant Recipients From a Single Donor"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3877-4314","authenticated-orcid":false,"given":"Charlotte","family":"Wigston","sequence":"first","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"},{"name":"Department of Respiratory Medicine, St John of God Midland Public and Private Hospitals , Midland, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Lavender","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Long","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dipen","family":"Sankhesara","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ching","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Weaire-Buchanan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine Western Australia, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shakeel","family":"Mowlaboccus","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine Western Australia, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"},{"name":"College of Science, Health, Engineering and Education, Murdoch University , Perth, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey W","family":"Coombs","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine Western Australia, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"},{"name":"College of Science, Health, Engineering and Education, Murdoch University , Perth, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn","family":"Lam","sequence":"additional","affiliation":[{"name":"Advanced Heart Failure Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"},{"name":"Department of Medicine, University of Notre Dame , Perth, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meow Cheong","family":"Yaw","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Musk","sequence":"additional","affiliation":[{"name":"Advanced Lung Disease Unit, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0518-0421","authenticated-orcid":false,"given":"Peter","family":"Boan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, PathWest Laboratory Medicine Western Australia, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"},{"name":"Department of Infectious Diseases, Fiona Stanley Hospital, Murdoch, Western Australia , Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"2023061319475798900_ofad263-B1","doi-asserted-by":"crossref","DOI":"10.1111\/ctr.14334","article-title":"Hyperammonemia syndrome associated with Ureaplasma 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