{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:01:08Z","timestamp":1768280468781,"version":"3.49.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005224","name":"National Center of Immunization and Respiratory Diseases","doi-asserted-by":"publisher","award":["75D30120C08008"],"award-info":[{"award-number":["75D30120C08008"]}],"id":[{"id":"10.13039\/100005224","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P &amp;lt; .001), cough (50.9%, 63.3%, 66.7%; P &amp;lt; .001), and runny noses (48.9%, 71.3%, 72.9%; P &amp;lt; .001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P &amp;lt; .001), shortness of breath (42.7%, 29.5%, 27.5%; P &amp;lt; .001), loss of taste (47.1%, 61.8%, 19.2%; P &amp;lt; .001), and loss of smell (47.5%, 55.6%, 20.0%; P &amp;lt; .001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26\u20133.35) and Delta (OR, 1.96; 95% CI, 1.69\u20132.28).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration<\/jats:title>\n                  <jats:p>NCT04610515.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad275","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:33:30Z","timestamp":1684888410000},"source":"Crossref","is-referenced-by-count":11,"title":["Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study\u2014December 20, 2020\u2014June 20, 2022"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5382-9486","authenticated-orcid":false,"given":"Ralph C","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, University of California San Francisco , San Francisco, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-8375","authenticated-orcid":false,"given":"Michael","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Rush University Medical Center , Chicago, Illinois , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos C","family":"Montoy","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, University of California San Francisco , San Francisco, California , 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