{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:42:09Z","timestamp":1781970129230,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Peruvian Ministry of Health"},{"name":"Partners In Health"},{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 AI141740"],"award-info":[{"award-number":["K08 AI141740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 AI060354"],"award-info":[{"award-number":["P30 AI060354"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Few studies have examined the burden of postacute sequelae of coronavirus disease 2019 (COVID-19) (PASC) in low- and middle-income countries. We sought to characterize PASC with self-reported questionnaires and clinical examinations of end-organ function in Lima, Peru.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>From January to July 2021, we recruited participants at least 8 weeks after COVID-19 diagnosis from a case registry in Lima, Peru. We evaluated participants for PASC with questionnaires, neuropsychiatric evaluations, chest X-ray, spirometry, electrocardiogram, and echocardiogram. We used multivariable models to identify risk factors for PASC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We assessed 989 participants for PASC at a median 4.7 months after diagnosis. Clinically significant respiratory symptoms were reported by 68.3% of participants, particularly those who had been severely ill during acute COVID-19, and were associated with cardiac findings of ventricular hypertrophy or dilation on echocardiogram. Neuropsychiatric questionnaires were consistent with depression in 20.7% and cognitive impairment in 8.0%. Female sex and older age were associated with increased risk of respiratory (adjusted odds ratio [aOR], 2.36 [95% confidence interval {CI}, 1.69\u20133.31] and aOR, 1.01 [95% CI, 1.00\u20131.03], respectively) and neuropsychiatric sequelae (aOR, 2.99 [95% CI, 2.16\u20134.18] and aOR, 1.02 [95% CI, 1.01\u20131.03], respectively).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>COVID-19 survivors in Lima, Peru, experienced frequent postacute respiratory symptoms and depression, particularly among older and female participants. Clinical examinations highlighted the need for cardiopulmonary rehabilitation among persons with severe COVID-19; psychosocial support may be required among all COVID-19 survivors.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad320","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T14:16:50Z","timestamp":1687011410000},"source":"Crossref","is-referenced-by-count":1,"title":["Respiratory, Cardiac, and Neuropsychiatric Manifestations of Postacute Sequelae of Coronavirus Disease 2019 in Lima, Peru"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-9312","authenticated-orcid":false,"given":"Rifat S","family":"Rahman","sequence":"first","affiliation":[{"name":"Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A","family":"Tovar","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"},{"name":"Escuela de Medicina, Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Peinado","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Santiago","family":"Palomino","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Redes Integradas de Salud\u2013Lima Norte , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Llanos-Zavalaga","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Redes Integradas de Salud\u2013Lima Norte , Lima , Peru"},{"name":"Faculty of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Peralta","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Redes Integradas de Salud\u2013Lima Norte , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gissela","family":"Valderrama","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes B","family":"Ramos Cordova","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucero I","family":"Sanchez Cortez","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"GRV Especialistas Cl\u00ednicos SAC , Lima , Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison N","family":"LaHood","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly F","family":"Franke","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole D","family":"Mitnick","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA"},{"name":"Division of Global Health Equity, Brigham and Women\u2019s Hospital , Boston, Massachusetts , USA"},{"name":"Partners In Health , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Lecca","sequence":"additional","affiliation":[{"name":"Socios En Salud Sucursal Peru , Lima , Peru"},{"name":"Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1438-0692","authenticated-orcid":false,"given":"Gustavo E","family":"Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Division of Global Health Equity, Brigham and Women\u2019s Hospital , Boston, Massachusetts , USA"},{"name":"UCSF Center for Tuberculosis, University of California, San Francisco , San Francisco, California , USA"},{"name":"Division of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco , San Francisco, California , 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