{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:23:47Z","timestamp":1770272627203,"version":"3.49.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":17,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002457","name":"Chosun University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002457","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases in Korea. Every year, an increasing number of cases are reported, which is a public health concern. Therefore, we aimed to investigate the prevalence of SFTS\u2013scrub typhus coinfection in patients with SFTS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Clinical samples were collected from 129 patients with SFTS. One-step reverse-transcription polymerase chain reaction (PCR) was performed to identify the SFTS virus (SFTSV), and real-time PCR followed by nested PCR was performed to detect the Orientia tsutsugamushi gene for scrub typhus. Phylogenetic analysis was conducted to confirm the evolutionary relationships among different species.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 129 SFTS cases, 2 patients with SFTSV were positive for O. tsutsugamushi with a prevalence of coinfection of 1.6% (95% confidence interval, .001\u2013.06). Phylogenetic analysis confirmed these as O. tsutsugamushi strain Boryong.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study found that 1.6% of patients were coinfected with SFTS and scrub typhus infection. We believe that this information will add a new dimension to clinical diagnosis, which should be considered for better public health management. Further research is needed to better understand the ecological transmission dynamics and geographical distribution of SFTSV and O. tsutsugamushi in endemic countries.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad377","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T11:56:44Z","timestamp":1697543804000},"source":"Crossref","is-referenced-by-count":6,"title":["Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea"],"prefix":"10.1093","volume":"10","author":[{"given":"Shilpa","family":"Chatterjee","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Me","family":"Kim","sequence":"additional","affiliation":[{"name":"Premedical Science, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-0922","authenticated-orcid":false,"given":"Dong-Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na-Ra","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Chosun University , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook In","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University Medical School , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uh Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University Medical School , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Eun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chonnam National University Medical School , Gwangju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Keimyung University Dongsan Hospital, Keimyung University 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Medicine, Chungbuk National University , Cheongju , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Yeon","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, School of Medicine, Ajou University , Suwon , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Sik","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine, Dong-A University , Busan , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyungdon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University , Chuncheon , Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Hee","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, 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