{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:31:10Z","timestamp":1788967870864,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T00:00:00Z","timestamp":1696204800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Merck Sharp & Dohme Investigator Initiated Studies Program"},{"name":"Stan Perron Charitable Foundation Fellowship"},{"DOI":"10.13039\/501100024253","name":"Future Health Research and Innovation Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024253","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Western Australian Near-miss Awards program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The association between early-life respiratory syncytial virus (RSV) infections and later respiratory morbidity is well established. However, there is limited evidence on factors that influence this risk. We examined sociodemographic and perinatal factors associated with later childhood respiratory morbidity requiring secondary care following exposure to a laboratory-confirmed RSV episode in the first 2 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We used a probabilistically linked whole-of-population-based birth cohort including 252 287 children born in Western Australia between 2000 and 2009 with follow-up to the end of 2012. Cox proportional hazards models estimated adjusted hazard ratios (aHRs) of the association of various risk factors with the first respiratory episode for asthma, wheezing, and unspecified acute lower respiratory infection beyond the age of 2 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The analytic cohort included 4151 children with a confirmed RSV test before age 2 years. The incidence of subsequent respiratory morbidity following early-life RSV infection decreased with child age at outcome (highest incidence in 2\u2013&amp;lt;4-year-olds: 41.8 per 1000 child-years; 95% CI, 37.5\u201346.6), increased with age at RSV infection (6\u2013&amp;lt;12-month-olds: 23.6\/1000 child-years; 95% CI, 19.9\u201327.8; 12\u2013&amp;lt;24-month-olds: 22.4\/1000 child-years; 95% CI, 18.2\u201322.7) and decreasing gestational age (50.8\/1000 child-years; 95% CI, 33.5\u201377.2 for children born extremely preterm, &amp;lt;28 weeks gestation). Risk factors included age at first RSV episode (6\u2013&amp;lt;12 months: aHR, 1.42; 95% CI, 1.06\u20131.90), extreme prematurity (&amp;lt;28 weeks: aHR, 2.22; 95% CI, 1.40\u20133.53), maternal history of asthma (aHR, 1.33; 95% CI, 1.04\u20131.70), and low socioeconomic index (aHR, 1.76; 95% CI, 1.03\u20133.00).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results suggest that in addition to preterm and young infants, children aged 12\u2013&amp;lt;24 months could also be potential target groups for RSV prevention to reduce the burden of later respiratory morbidities associated with RSV.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad450","type":"journal-article","created":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:18:27Z","timestamp":1696259907000},"source":"Crossref","is-referenced-by-count":5,"title":["Factors Predicting Secondary Respiratory Morbidity Following Early-Life Respiratory Syncytial Virus Infections: Population-Based Cohort Study"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2448-1588","authenticated-orcid":false,"given":"Mohinder","family":"Sarna","sequence":"first","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia , Perth, Western Australia , Australia"},{"name":"Curtin School of Population Health, Curtin University , Bentley, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanuel","family":"Gebremedhin","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia , Perth, Western Australia , Australia"},{"name":"Curtin School of Population Health, Curtin University , Bentley, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C","family":"Richmond","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia , Perth, Western Australia , Australia"},{"name":"School of Medicine, University of Western Australia , Nedlands, Western Australia , Australia"},{"name":"Perth Children's Hospital , Nedlands, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Glass","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia , Perth, Western Australia , Australia"},{"name":"National Centre for Epidemiology and Population Health, ANU College of Health and Medicine, Australian National University , Canberra, Australian Capital Territory , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avram","family":"Levy","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine, QEII Medical Centre , Nedlands, Perth, Western Australia , Australia"},{"name":"School of Biomedical Sciences, University of Western Australia , Nedlands, Perth, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C","family":"Moore","sequence":"additional","affiliation":[{"name":"Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia , Perth, Western Australia , Australia"},{"name":"Curtin School of Population Health, Curtin University , Bentley, Western Australia , Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,2]]},"reference":[{"key":"2023100215181437900_ofad450-B1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis","volume":"399","author":"Li","year":"2022","journal-title":"Lancet"},{"key":"2023100215181437900_ofad450-B2","doi-asserted-by":"crossref","first-page":"e025360","DOI":"10.1136\/bmjopen-2018-025360","article-title":"Geographical disparities in emergency department presentations for acute respiratory infections and risk factors for presenting: a population-based cohort study of Western Australian children","volume":"9","author":"Barnes","year":"2019","journal-title":"BMJ 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