{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:03:55Z","timestamp":1777100635223,"version":"3.51.4"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scantlebury Wellcome Trust ISSF Fellowship","award":["204822\/Z\/16\/Z"],"award-info":[{"award-number":["204822\/Z\/16\/Z"]}]},{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["GC6-74"],"award-info":[{"award-number":["GC6-74"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Inclusion of Histoplasma in the World Health Organization's first Fungal Priority Pathogens List under \u201chigh-priority\u201d fungal species highlights the need for robust surveillance of Histoplasma spp. in endemic and underrepresented regions. Despite increasing reports of histoplasmosis in Africa, data on the burden of this fungal disease are sparse in The Gambia. This baseline study examined the human seroprevalence of anti-Histoplasma antibody in a TB patient group in The Gambia, explored associations between seropositivity and demographic and clinical variables, and proposes future research directions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Biobanked plasma samples were selected from active TB cases with variable HIV infection status. Latex agglutination tests were performed on samples from 52 study participants to detect the presence of anti-Histoplasma antibodies. Potential risk factors for Histoplasma exposure were explored using logistic regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The sample seroprevalence of anti-Histoplasma antibody was 28.8% (n = 15\/52; 95% CI, 17.1%\u201343.1%). Multivariable logistic regression analysis identified a statistically significant association between Histoplasma seropositivity and age (odds ratio, 0.91; 95% CI, 0.84\u20130.98; P = .008).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This baseline study provides evidence of Histoplasma seropositivity in TB patients in The Gambia and explores risk factors for exposure. The small sample size and use of the LAT in TB and HIV-positive patient groups are significant study limitations. Future research directions are proposed to ascertain the burden of Histoplasma in general and patient populations and explore the context-specific risk factors for exposure and infection in The Gambia.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad510","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T17:16:18Z","timestamp":1697217378000},"source":"Crossref","is-referenced-by-count":3,"title":["<i>Histoplasma<\/i> Seropositivity in TB Patients in The Gambia: Evidence to Drive Research on a High-Priority Fungal Pathogen"],"prefix":"10.1093","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2304-8555","authenticated-orcid":false,"given":"Tessa R","family":"Cornell","sequence":"first","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool , Liverpool , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dawda","family":"Jobe","sequence":"additional","affiliation":[{"name":"Vaccines and Immunity Theme, MRC Unit The Gambia, London School of Hygiene and Tropical Medicine , Fajara , The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Donkor","sequence":"additional","affiliation":[{"name":"Vaccines and Immunity Theme, MRC Unit The Gambia, London School of Hygiene and Tropical Medicine , Fajara , The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel G","family":"Wootton","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool , Liverpool , UK"},{"name":"NIHR Health Protection Research Unit in Emerging and Zoonotic Diseases, University of Liverpool , Liverpool , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Pinchbeck","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool , Liverpool , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayne S","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Vaccines and Immunity Theme, MRC Unit The Gambia, London School of Hygiene and Tropical Medicine , Fajara , The Gambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire Elizabeth","family":"Scantlebury","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary and Ecological Sciences (IVES), University of Liverpool , Liverpool , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"2023110307491373100_ofad510-B1","volume-title":"WHO Fungal Priority Pathogens List to Guide Research, Development and Public Health Action","author":"World Health Organization","year":"2022"},{"key":"2023110307491373100_ofad510-B2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4269\/ajtmh.2011.10-0251","article-title":"Short report: what is AIDS in the Amazon and the guianas? 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