{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:32:36Z","timestamp":1770748356794,"version":"3.50.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173579"],"award-info":[{"award-number":["82173579"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yi-Wu Research Institute of Fudan University","award":["KCF201512"],"award-info":[{"award-number":["KCF201512"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Frailty is one of the major concerns among aging people with HIV (PWH). Evidence regarding the association between sleep disorders and physical frailty in PWH is limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>PWH and HIV-negative individuals aged \u226540 years were included and frequency-matched in a 1:2 ratio by sex and age. Logistic regression models were used to estimate the odds ratios (ORs) and 95% CIs of the association between sleep disorders and physical frailty, and restricted cubic splines were used to describe the dose\u2013response association. The contribution of depression to the association was estimated by mediation analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 1526 PWH and 3052 HIV-negative individuals were included. Logistic regression indicated that insomnia (OR, 3.05; 95% CI, 1.63\u20135.72) and poor sleep quality (OR, 2.32; 95% CI, 1.21\u20134.45) were significantly associated with physical frailty in middle-aged and older PWH, especially in those with current CD4+ T-cell counts &amp;lt;350 cells\/\u00b5L, but not in HIV-negative participants. A U-shaped and J-shaped dose\u2013response relation between sleep duration and physical frailty was observed in PWH and HIV-negative participants, respectively. Shorter and longer sleep duration was associated with an increased risk of physical frailty in PWH. However, in HIV-negative participants, only longer sleep duration was associated with physical frailty. Mediation analysis revealed that depression mediated the relation between sleep disorders and frailty among PWH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Sleep disorders including insomnia, poor sleep quality, and short and long sleep duration were significantly associated with physical frailty among middle-aged and older PWH. Depression may play a mediating role in the sleep\u2013frailty association.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad566","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T11:15:40Z","timestamp":1699528540000},"source":"Crossref","is-referenced-by-count":8,"title":["Association of Insomnia, Sleep Quality, and Sleep Duration With Risk of Physical Frailty in Middle-aged and Older People With HIV"],"prefix":"10.1093","volume":"10","author":[{"given":"Qionggui","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University , Shanghai , China"},{"name":"Yi-Wu Research Institute, Fudan University , Shanghai , China"},{"name":"Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University , Shanghai , China"},{"name":"Yi-Wu Research Institute, Fudan University , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University , Shanghai , China"},{"name":"Taizhou City Center for Disease Control and Prevention , Taizhou, Zhejiang Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanling","family":"Wang","sequence":"additional","affiliation":[{"name":"Taizhou City Center for Disease Control and Prevention , Taizhou, Zhejiang Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University , Shanghai , China"},{"name":"Taizhou City Center for Disease Control and Prevention , Taizhou, Zhejiang Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"He","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, and Key Laboratory of Public Health Safety of Ministry of Education, Fudan University , Shanghai , China"},{"name":"Yi-Wu Research Institute, Fudan University , Shanghai , China"},{"name":"Shanghai Institute of Infectious Diseases and Biosecurity, Fudan University , Shanghai , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"2023112917282746300_ofad566-B1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/QAD.0000000000000078","article-title":"Cause-specific mortality among HIV-infected individuals, by CD4(+) R cell count at HAART initiation, compared with HIV-uninfected individuals","volume":"28","author":"Wada","year":"2014","journal-title":"AIDS"},{"key":"2023112917282746300_ofad566-B2","doi-asserted-by":"crossref","first-page":"d6016","DOI":"10.1136\/bmj.d6016","article-title":"Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) study","volume":"343","author":"May","year":"2011","journal-title":"BMJ"},{"key":"2023112917282746300_ofad566-B3","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijid.2022.11.030","article-title":"The association between physical frailty and injurious falls and all-cause mortality as negative health outcomes in people living with HIV: a systematic review and meta-analysis","volume":"126","author":"Zhou","year":"2023","journal-title":"Int J Infect Dis"},{"key":"2023112917282746300_ofad566-B4","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1097\/QAD.0000000000001613","article-title":"Frailty is strongly associated with increased risk of recurrent falls among older HIV-infected adults","volume":"31","author":"Tassiopoulos","year":"2017","journal-title":"AIDS"},{"key":"2023112917282746300_ofad566-B5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/QAI.0000000000000341","article-title":"An adapted frailty-related phenotype and the VACS index as predictors of hospitalization and mortality in HIV-infected and uninfected individuals","volume":"67","author":"Akgun","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2023112917282746300_ofad566-B6","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.sleep.2019.06.020","article-title":"Cross-sectional comparison of various sleep disturbances among sex- and age-matched HIV-infected versus HIV-uninfected individuals in China","volume":"65","author":"Ning","year":"2020","journal-title":"Sleep Med"},{"key":"2023112917282746300_ofad566-B7","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.sleep.2015.03.027","article-title":"Self-reported sleep disturbances in HIV-infected people: a meta-analysis of prevalence and moderators","volume":"16","author":"Wu","year":"2015","journal-title":"Sleep Med"},{"key":"2023112917282746300_ofad566-B8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neubiorev.2017.01.032","article-title":"Cooccurrence and bidirectional prediction of sleep disturbances and depression in older adults: meta-analysis and systematic review","volume":"75","author":"Bao","year":"2017","journal-title":"Neurosci Biobehav R"},{"key":"2023112917282746300_ofad566-B9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.maturitas.2020.03.005","article-title":"Insomnia, low sleep quality, and sleeping little are associated with frailty in Mexican women","volume":"136","author":"Moreno-Tamayo","year":"2020","journal-title":"Maturitas"},{"key":"2023112917282746300_ofad566-B10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1186\/s12877-021-02455-9","article-title":"Long sleep duration is associated with cognitive frailty among older community-dwelling adults: results from West China health and aging trend study","volume":"21","author":"Zhao","year":"2021","journal-title":"BMC Geriatr"},{"key":"2023112917282746300_ofad566-B11","doi-asserted-by":"crossref","first-page":"963105","DOI":"10.3389\/fpubh.2022.963105","article-title":"Association of sleep quality and nap duration with cognitive frailty among older adults living in nursing homes","volume":"10","author":"Liu","year":"2022","journal-title":"Front Public Health"},{"key":"2023112917282746300_ofad566-B12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.gerinurse.2021.02.020","article-title":"Sleep quality, depression and frailty among Chinese community-dwelling older adults","volume":"42","author":"Liu","year":"2021","journal-title":"Geriatr Nurs"},{"key":"2023112917282746300_ofad566-B13","doi-asserted-by":"crossref","first-page":"E860","DOI":"10.1016\/S2352-3018(19)30263-2","article-title":"Age-specific associations between HIV infection and carotid artery intima-media thickness in China: a cross-sectional evaluation of baseline data from the CHART cohort","volume":"6","author":"Lin","year":"2019","journal-title":"Lancet Hiv"},{"key":"2023112917282746300_ofad566-B14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.1965.01720310065008","article-title":"A self-rating depression scale","volume":"12","author":"Zung","year":"1965","journal-title":"Arch Gen Psychiatry"},{"key":"2023112917282746300_ofad566-B15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1891\/1521-0987.11.4.210","article-title":"The use of the zung self-rating depression scale to assist in the case management of patients living with HIV\/AIDS","volume":"11","author":"Lombardi","year":"2010","journal-title":"Care Manag J"},{"key":"2023112917282746300_ofad566-B16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s13365-021-01036-1","article-title":"Interaction of declined handgrip strength and HIV infection on neurocognitive impairment","volume":"28","author":"Yuan","year":"2022","journal-title":"J Neurovirol"},{"key":"2023112917282746300_ofad566-B17","first-page":"83","article-title":"Cooperative meta-analysis group of the China Obesity Task Force. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut-off points of body mass index and waist circumference in Chinese adults [in Chinese]","volume":"15","author":"Zhou","year":"2002","journal-title":"Biomed Environ Sci"},{"key":"2023112917282746300_ofad566-B18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"2023112917282746300_ofad566-B19","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.sleh.2014.12.010","article-title":"National sleep Foundation's sleep time duration recommendations: methodology and results summary","volume":"1","author":"Hirshkowitz","year":"2015","journal-title":"Sleep Health"},{"key":"2023112917282746300_ofad566-B20","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1365-2869.2010.00884.x","article-title":"Association between sleep duration and all-cause mortality in old age: 9-year follow-up of the Bambui Cohort Study, Brazil","volume":"20","author":"Castro-Costa","year":"2011","journal-title":"J Sleep Res"},{"key":"2023112917282746300_ofad566-B21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0895-4356(88)90138-2","article-title":"A scale for the estimation of sleep problems in clinical research","volume":"41","author":"Jenkins","year":"1988","journal-title":"J Clin Epidemiol"},{"key":"2023112917282746300_ofad566-B22","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2023112917282746300_ofad566-B23","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/hiv.13429","article-title":"Associations between HIV infection and frailty status and its individual components: are frailty components disproportionally affected?","volume":"24","author":"Li","year":"2023","journal-title":"HIV Med"},{"key":"2023112917282746300_ofad566-B24","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/21645515.2019.1643677","article-title":"Immunogenicity and safety of 13-valent pneumococcal conjugate vaccine in HIV-infected adults in the era of highly active antiretroviral therapy: analysis stratified by CD4 T-cell count","volume":"16","author":"Song","year":"2020","journal-title":"Hum Vaccin Immunother"},{"key":"2023112917282746300_ofad566-B25","volume-title":"Introduction to Mediation, Moderation, and Conditional Process Analysis: A Regression-Based Approach","author":"Hayes","year":"2022"},{"key":"2023112917282746300_ofad566-B26","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1017\/SJP.2021.46","article-title":"Mediation, moderation, and conditional process analysis: concepts, computations, and some common confusions","volume":"24","author":"Igartua","year":"2021","journal-title":"Span J Psychol"},{"key":"2023112917282746300_ofad566-B27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1086\/651257","article-title":"Reconsidering Baron and Kenny: myths and truths about mediation analysis","volume":"37","author":"Zhao","year":"2010","journal-title":"J Consum Res"},{"key":"2023112917282746300_ofad566-B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/cjn.2023.6","article-title":"Mediation of post-stroke function by cognition in the Canadian Longitudinal Study on Aging","author":"Joundi","year":"2023","journal-title":"Can J Neurol Sci"},{"key":"2023112917282746300_ofad566-B29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/infdis\/jix032","article-title":"Higher prevalence of frailty among a sample of HIV-infected middle-aged and older Chinese adults is associated with neurocognitive impairment and depressive symptoms","volume":"215","author":"Ding","year":"2017","journal-title":"J Infect Dis"},{"key":"2023112917282746300_ofad566-B30","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/geronb\/gbab027","article-title":"Links between inflammation, mood, and physical function among older adults with HIV","volume":"77","author":"Derry","year":"2022","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"2023112917282746300_ofad566-B31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0898264318803470","article-title":"Long sleep duration is associated with increased frailty risk in older community-dwelling adults","volume":"32","author":"Baniak","year":"2020","journal-title":"J Aging Health"},{"key":"2023112917282746300_ofad566-B32","article-title":"Associations of sleep quality and sleep duration with frailty and pre-frailty in an elderly population Rugao Longevity and Ageing Study","volume":"20:9","author":"Sun","year":"2020","journal-title":"BMC Geriatr"},{"key":"2023112917282746300_ofad566-B33","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12603-018-1109-2","article-title":"Sleep latency in men and sleep duration in women can be frailty markers in community-dwelling older adults: the Korean Frailty and Aging Cohort Study (KFACS)","volume":"23","author":"Kang","year":"2019","journal-title":"J Nutr Health Aging"},{"key":"2023112917282746300_ofad566-B34","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/apc.2010.0375","article-title":"Quality of sleep: associations with antiretroviral nonadherence","volume":"25","author":"Saberi","year":"2011","journal-title":"AIDS Patient Care STDS"},{"key":"2023112917282746300_ofad566-B35","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/821710","article-title":"Examining the pathways linking chronic sleep restriction to obesity","volume":"2010","author":"Magee","year":"2010","journal-title":"J Obes"},{"key":"2023112917282746300_ofad566-B36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bbi.2014.06.004","article-title":"C-reactive protein and depression in persons with human immunodeficiency virus infection: the Positive Living With HIV (POLH) study","volume":"42","author":"Poudel-Tandukar","year":"2014","journal-title":"Brain Behav Immun"},{"key":"2023112917282746300_ofad566-B37","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1001\/archinte.164.9.1010","article-title":"Depression and C-reactive protein in US adults: data from the Third National Health and Nutrition Examination Survey","volume":"164","author":"Ford","year":"2004","journal-title":"Arch Intern Med"},{"key":"2023112917282746300_ofad566-B38","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1007\/s10461-014-0949-y","article-title":"Association of markers of inflammation with sleep and physical activity among people living with HIV or AIDS","volume":"19","author":"Wirth","year":"2015","journal-title":"AIDS Behav"},{"key":"2023112917282746300_ofad566-B39","first-page":"228","article-title":"Inflammation, immune activation, immunosenescence, and hormonal biomarkers in the frailty-related phenotype of men with or at risk for HIV infection","volume":"215","author":"Erlandson","year":"2017","journal-title":"J Infect Dis"},{"key":"2023112917282746300_ofad566-B40","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00126334-200112010-00015","article-title":"Higher efavirenz plasma levels correlate with development of insomnia","volume":"28","author":"Nunez","year":"2001","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2023112917282746300_ofad566-B41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1046\/j.1468-1293.2003.00136.x","article-title":"Long-term assessment of neuropsychiatric adverse reactions associated with efavirenz","volume":"4","author":"Lochet","year":"2003","journal-title":"HIV Med"},{"key":"2023112917282746300_ofad566-B42","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1212\/WNL.0b013e318200d727","article-title":"HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: cHARTER study","volume":"75","author":"Heaton","year":"2010","journal-title":"Neurology"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofad566\/53180077\/ofad566.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/10\/11\/ofad566\/53928318\/ofad566.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/10\/11\/ofad566\/53928318\/ofad566.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T17:29:32Z","timestamp":1701278972000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofad566\/7394927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofad566","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11]]},"published":{"date-parts":[[2023,11,1]]},"article-number":"ofad566"}}