{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T02:56:46Z","timestamp":1768877806959,"version":"3.49.0"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EIP","award":["U50CK000485"],"award-info":[{"award-number":["U50CK000485"]}]},{"name":"Georgia EIP"},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006939","name":"Emory University","doi-asserted-by":"publisher","award":["CP154653"],"award-info":[{"award-number":["CP154653"]}],"id":[{"id":"10.13039\/100006939","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Incidence estimates of Staphylococcus aureus infections rarely include the full spectrum of clinically relevant disease from both community and healthcare settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective study capturing all S aureus infections in Fulton County, Georgia, during 2017. Medical records of patients with any incident infection (clinical cultures growing S aureus from any site, without prior positive culture in previous 14 days) were reviewed. Estimates of disease incidence were calculated using age-, race-, and sex-specific population denominators accounting for weighted sampling methods. Multivariable logistic regression models were used to identify risk factors for hospitalization among patients with skin and soft tissue infections (SSTIs).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall incidence of clinically relevant S aureus infection was 405.7 cases per 100 000 people (standard error [SE], 5.62 [range, 400.1\u2013411.3]). Overall incidence for those of Black race was 500.84 cases per 100 000 people (SE, 14.55), whereas White patients had overall incidence of 363.67 cases per 100 000 people (SE, 13.8). SSTIs were the most common infection (2351; 225.8 cases per 100 000 people [SE, 7.1]), and 30% required hospitalization. Among SSTIs, after adjusting for invasive disease, cellulitis, diabetes, and demographics, independent predictors of hospitalization included methicillin-resistant S aureus (adjusted odds ratio [aOR], 1.6 [95% confidence interval {CI}, 1.0\u20132.7]) and homelessness (aOR, 4.9 [95% CI, 1.1\u201322]).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The burden of clinically relevant S aureus infections is high, particularly among the Black population, and risks for hospitalization among SSTIs include isolate factors and factors related to patients\u2019 vulnerability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad601","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T23:48:49Z","timestamp":1701820129000},"source":"Crossref","is-referenced-by-count":2,"title":["Estimating the Burden of Clinically Significant <i>Staphylococcus aureus<\/i> Infections and Predictors for Hospitalization for Skin and Soft Tissue Infections, Fulton County, Georgia, 2017"],"prefix":"10.1093","volume":"10","author":[{"given":"Katherine I","family":"Phillip","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health, Emory University , Atlanta, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S","family":"Webster","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory School of Medicine , Atlanta, Georgia , USA"},{"name":"Department of Research, Atlanta Veterans Affairs Medical Center , Decatur, Georgia , USA"},{"name":"Georgia Emerging Infections Program , Decatur, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-088X","authenticated-orcid":false,"given":"Susan M","family":"Ray","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory School of Medicine , Atlanta, Georgia , USA"},{"name":"Georgia Emerging Infections Program , Decatur, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Britton","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory School of Medicine , Atlanta, Georgia , USA"},{"name":"Department of Research, Atlanta Veterans Affairs Medical Center , Decatur, Georgia , USA"},{"name":"Georgia Emerging Infections Program , Decatur, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Swerdlow","sequence":"additional","affiliation":[{"name":"Medical Development and Scientific\/Clinical Affairs, Pfizer Vaccines , Collegeville, Pennsylvania , USA"},{"name":"Medical Affairs, HilleVax Inc, Boston, Massachusetts , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4892-693X","authenticated-orcid":false,"given":"Scott K","family":"Fridkin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory School of Medicine , Atlanta, Georgia , USA"},{"name":"Georgia Emerging Infections Program , Decatur, Georgia , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,7]]},"reference":[{"key":"2023122900460060700_ofad601-B1","first-page":"1970","article-title":"National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011","volume":"173","author":"Dantes","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2023122900460060700_ofad601-B2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.15585\/mmwr.mm6809e1","article-title":"Vital signs: epidemiology and recent trends in methicillin-resistant and in methicillin-susceptible Staphylococcus aureus bloodstream infections\u2014United States","volume":"68","author":"Kourtis","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2023122900460060700_ofad601-B3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/656431","article-title":"Skin and soft-tissue infections requiring hospitalization at an academic medical center: opportunities for antimicrobial stewardship","volume":"51","author":"Jenkins","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2023122900460060700_ofad601-B4","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1017\/S0950268816001709","article-title":"Predictors of community-associated Staphylococcus aureus, methicillin-resistant and methicillin-susceptible Staphylococcus aureus skin and soft tissue infections in primary-care settings","volume":"144","author":"Lee","year":"2016","journal-title":"Epidemiol 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States","volume":"298","author":"Klevens","year":"2007","journal-title":"JAMA"},{"key":"2023122900460060700_ofad601-B11","author":"Georgia Department of Public Health, Office of Health Indicators for Planning"},{"key":"2023122900460060700_ofad601-B12","author":"Lumley","year":"2023"},{"key":"2023122900460060700_ofad601-B13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/cid\/ciy277","article-title":"Racial disparities in invasive methicillin-resistant Staphylococcus aureus infections, 2005\u20132014","volume":"67","author":"Gualandi","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2023122900460060700_ofad601-B14","doi-asserted-by":"crossref","first-page":"e059327","DOI":"10.1136\/bmjopen-2021-059327","article-title":"Risk factors for non-invasive (skin and soft tissue) and invasive Staphylococcus aureus infections among children and adults living in southeastern USA: a retrospective cohort 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