{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:02:52Z","timestamp":1753876972527,"version":"3.41.2"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The conventional diagnostic for Schistosoma mansoni infection is stool microscopy with the Kato-Katz (KK) technique to detect eggs. Its outcomes are highly variable on a day-to-day basis and may lead to biased estimates of community infection used to inform public health programs. Our goal is to develop a resampling method that leverages data from a large-scale randomized trial to accurately predict community infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We developed a resampling method that provides unbiased community estimates of prevalence, intensity and other statistics for S mansoni infection when a community survey is conducted using KK stool microscopy with a single sample per host. It leverages a large-scale data set, collected in the Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) project, and allows linking single\u2014stool specimen community screening to its putative multiday \u201ctrue statistics.\u201d<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>SCORE data analysis reveals the limited sensitivity of KK stool microscopy and systematic bias of single-day community testing versus multiday testing; for prevalence estimate, it can fall up to 50% below the true value. The proposed SCORE cluster method reduces systematic bias and brings the estimated prevalence values within 5%\u201310% of the true value. This holds for a broad swath of transmission settings, including SCORE communities, and other data sets.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our SCORE cluster method can markedly improve the S mansoni prevalence estimate in settings using stool microscopy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad659","type":"journal-article","created":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T14:30:51Z","timestamp":1703169051000},"source":"Crossref","is-referenced-by-count":0,"title":["Improved Assessment of <i>Schistosoma<\/i> Community Infection Through Data Resampling Method"],"prefix":"10.1093","volume":"11","author":[{"given":"David","family":"Gurarie","sequence":"first","affiliation":[{"name":"Department of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University , Cleveland, Ohio , USA"},{"name":"Center for Global Health and Diseases, School of Medicine, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University , Cleveland, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4158-7613","authenticated-orcid":false,"given":"Martial L","family":"Ndeffo-Mbah","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Integrative Biosciences, School of Veterinary Medicine and Biomedical Sciences, Texas A&M University , College Station, Texas , USA"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University , College Station, Texas , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"2024021622371610800_ofad659-B1","doi-asserted-by":"crossref","first-page":"e3139","DOI":"10.1371\/journal.pntd.0003139","article-title":"Sensitivity and specificity of multiple Kato-Katz thick smears and a circulating cathodic antigen test for Schistosoma mansoni diagnosis pre- and post-repeated-praziquantel treatment","volume":"8","author":"Lamberton","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"2024021622371610800_ofad659-B2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1017\/S003118200200207X","article-title":"Estimating the distribution of worm burden and egg excretion of Schistosoma japonicum by risk group in Sichuan Province, 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