{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:43:53Z","timestamp":1789789433307,"version":"4.0.1"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The incidence of osteonecrosis of the femoral head (ONFH) in people with human immunodeficiency virus (HIV) is 10\u2013100 times higher than that in the general population. However, the specific bone microstructure and extent of damage within the femoral head in PWH are still unclear.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Femoral head samples were obtained by total hip arthroplasty, micro\u2013computed tomography (micro-CT) was employed to investigate the microstructure of trabecular bone across 4 representative regions within necrotic femoral heads, and quantitative analysis was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>On general observation, different degrees of degenerative cartilage, fibrocartilage, hyperplastic bone, and exposed bone were presented alternately, with a \u201cmap-like\u201d appearance. On micro-CT, compared with the normal and necrotic areas, the bone volume\/tissue volume and bone mineral density of the sclerotic areas were significantly increased, the number of trabeculae was significantly increased, and the gap was smaller (P &amp;lt; .05). There was no significant difference in trabecular thickness among the groups (P &amp;lt; .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The systemic immune syndrome caused by HIV itself may interfere with the normal metabolism of bone, including osteoblasts and osteoclasts, and thus participate in HIV-related ONFH.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofad660","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:55:47Z","timestamp":1702976147000},"source":"Crossref","is-referenced-by-count":3,"title":["Osteonecrosis of the Femoral Head in People Living With Human Immunodeficiency Virus: A Micro\u2013Computed Tomography Study"],"prefix":"10.1093","volume":"11","author":[{"given":"Kangpeng","family":"Li","sequence":"first","affiliation":[{"name":"National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ma","sequence":"additional","affiliation":[{"name":"National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Xu","sequence":"additional","affiliation":[{"name":"National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Center for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"2024020218184583800_ofad660-B1","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/apc.2023.0028","article-title":"HIV tissue reservoirs: current advances in research","volume":"37","author":"Li","year":"2023","journal-title":"AIDS Patient Care STDS"},{"key":"2024020218184583800_ofad660-B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.clinbiochem.2022.05.006","article-title":"Towards achieving the end of the HIV epidemic: advances, challenges and scaling-up strategies","volume":"117","author":"Balogun","year":"2023","journal-title":"Clin Biochem"},{"key":"2024020218184583800_ofad660-B3","first-page":"e21-00176","article-title":"Osteonecrosis of the femoral head","volume":"6","author":"George","year":"2022","journal-title":"J Am Acad Orthop Surg Glob Res 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