{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:29:39Z","timestamp":1792175379214,"version":"4.4.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Emerging and Pandemic Infections Consortium"},{"DOI":"10.13039\/100011094","name":"Public Health Agency of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MRR 184812"],"award-info":[{"award-number":["MRR 184812"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tier 2 Canada Research Chair in HIV Prevention and STI Research","award":["950-232641"],"award-info":[{"award-number":["950-232641"]}]},{"name":"Tier 2 Canada Research Chair in Mathematical Modeling and Program Science","award":["950-232643"],"award-info":[{"award-number":["950-232643"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Longitudinal data on the detectability of monkeypox virus (MPXV) genetic material in different specimen types are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe MPXV-specific polymerase chain reaction (PCR) results from adults with confirmed mpox infection from Toronto, Canada, including a cohort undergoing weekly collection of specimens from multiple anatomic sites until 1 week after skin lesions had fully healed. We quantified the time from symptom onset to resolution of detectable viral DNA (computed tomography [Ct] \u2265 35) by modeling exponential decay in Ct value as a function of illness day for each site, censoring at the time of tecovirimat initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 64 men who have sex with men, the median (interquartile range [IQR]) age was 39 (32.75\u201345.25) years, and 49% had HIV. Twenty received tecovirimat. Viral DNA was detectable (Ct &amp;lt; 35) at baseline in 74% of genital\/buttock\/perianal skin swabs, 56% of other skin swabs, 44% of rectal swabs, 37% of throat swabs, 27% of urine, 26% of nasopharyngeal swabs, and 8% of semen samples. The median time to resolution of detectable DNA (IQR) was longest for genital\/buttock\/perianal skin and other skin swabs at 30.0 (23.0\u201347.9) and 22.4 (16.6\u201329.4) days, respectively, and shortest for nasopharyngeal swabs and semen at 0 (0\u201312.1) and 0 (0\u20130) days, respectively. We did not observe an effect of tecovirimat on the rate of decay in viral DNA detectability in any specimen type (all P &amp;gt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MPXV DNA detectability varies by specimen type and persists for over 3\u20134 weeks in skin specimens. The rate of decay did not differ by tecovirimat use in this nonrandomized study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofae073","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T16:19:23Z","timestamp":1707149963000},"source":"Crossref","is-referenced-by-count":11,"title":["Longitudinal Analysis of Mpox Virus DNA Detectability From Multiple Specimen Types During Acute Illness: A Cohort Study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3069-2875","authenticated-orcid":false,"given":"Darrell H S","family":"Tan","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, St. Michael's Hospital , Toronto, Ontario , Canada"},{"name":"MAP Centre for Urban Health Solutions, St. Michael's Hospital , Toronto, Ontario , Canada"},{"name":"Department of Medicine, University of Toronto , Toronto, Ontario , Canada"},{"name":"Institute of Medical Science, University of Toronto , 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Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda R","family":"Taggart","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, St. Michael's Hospital , Toronto, Ontario , Canada"},{"name":"Department of Medicine, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Tan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, St. Michael's Hospital , Toronto, Ontario , Canada"},{"name":"Department of Medicine, University of Toronto , Toronto, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, St. Michael's Hospital , Toronto, Ontario , Canada"},{"name":"Department of Medicine, University of Toronto , Toronto, Ontario , 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