{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:12:31Z","timestamp":1790741551194,"version":"4.1.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":95,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["18-CE17-0008"],"award-info":[{"award-number":["18-CE17-0008"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2018, the US Food and Drug Administration approved the macrocylic lactone moxidectin (MOX) at 8\u2005mg dosage for onchocerciasis treatment in individuals aged \u226512 years. Severe adverse reactions have occurred after ivermectin (IVM), also a macrocyclic lactone, in individuals with high Loa microfilarial density (MFD). This study compared the safety and efficacy of a 2\u2005mg MOX dose and the standard 150\u2005\u00b5g\/kg IVM dose in individuals with low L loa MFD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A double-blind, randomized, ivermectin-controlled trial of a 2\u2005mg moxidectin dose was conducted in Cameroon between May and July 2022. It enrolled 72 adult men with L loa MFD between 5 and 1000 microfilariae\/mL. Outcomes were occurrence of adverse events (AEs) and L loa MFD reduction rate during the first month off treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No serious or severe AEs occurred among the 36 MOX- or the 36 IVM-treated individuals. Forty-nine AEs occurred in the MOX arm versus 59 AEs in the IVM arm. Grade 2 AE incidence was higher among IVM- than MOX-treated participants (38.5% and 14.3%, respectively, P = .043). Median MFD reduction rates were significantly higher after IVM than MOX at day 3 (70.2% vs 48.5%), day 7 (76.4% vs 50.0%), and day 30 (79.8% vs 48.1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A single 2\u2005mg MOX dose is as safe as 150\u2005\u00b5g\/kg IVM in patients with low L loa MFD. Further studies with higher MOX doses and in patients with higher MFD are warranted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Clinical Trials Registration<\/jats:title>\n                  <jats:p>NCT04049851.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae240","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T17:57:52Z","timestamp":1714067872000},"source":"Crossref","is-referenced-by-count":5,"title":["Safety and Short-term Efficacy of a Single Dose of 2\u2005mg Moxidectin in <i>Loa loa<\/i>\u2013Infected Individuals: A Double-Blind, Randomized Ivermectin-Controlled Trial With Ascending Microfilarial Densities"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6192-9580","authenticated-orcid":false,"given":"Guy S","family":"Wafeu","sequence":"first","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan M","family":"Lepage","sequence":"additional","affiliation":[{"name":"TransVIHMI, Universit\u00e9 de Montpellier, Inserm Unit\u00e9 1175, Institut de Recherche pour le D\u00e9veloppement , Montpellier , France"},{"name":"Department of Infectious and Tropical Diseases, Montpellier University Hospital , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy T","family":"Campillo","sequence":"additional","affiliation":[{"name":"TransVIHMI, Universit\u00e9 de Montpellier, Inserm Unit\u00e9 1175, Institut de Recherche pour le D\u00e9veloppement , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnauld","family":"Efon-Ekangouo","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues-Clotaire","family":"Nana-Djeunga","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narcisse","family":"Nzune-Toche","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-5526","authenticated-orcid":false,"given":"Andr\u00e9","family":"Domche","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , 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Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bopda","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves Aubin","family":"Balog","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Niamsi-Emalio","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e8ve","family":"Mbickmen-Tchana","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gervais Kamga","family":"Talla","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick S\u00e9drick Nguedia","family":"Kana","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9licit\u00e9 Diane Maga","family":"Messina","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien D","family":"Pion","sequence":"additional","affiliation":[{"name":"TransVIHMI, Universit\u00e9 de Montpellier, Inserm Unit\u00e9 1175, Institut de Recherche pour le D\u00e9veloppement , Montpellier , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette C","family":"Kuesel","sequence":"additional","affiliation":[{"name":"Special Programme for Research and Training in Tropical Diseases, United Nations Children\u2019s Fund\/United Nations Development Programme\/World Bank\/World Health Organization , Geneva , Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Kamgno","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistic Department, Higher Institute of Scientific and Medical Research , Yaound\u00e9 , Cameroon"},{"name":"Department of Public Health, Faculty of Medicine and Biomedical Sciences, University of Yaound\u00e9 I , Yaound\u00e9 , 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