{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:20:17Z","timestamp":1788405617755,"version":"build-2803163510"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extracorporeal membrane oxygenation (ECMO) is a life-saving technique used in critical care medicine for patients with severe respiratory or cardiac failure. This review examines the treatment and prophylaxis of fungal infections in ECMO patients, proposing specific regimens based on available data for different antifungals (azoles, echinocandins, amphotericin B\/liposomal amphotericin B) and invasive fungal infections. Currently, isavuconazole and posaconazole have the most supported data, while modified dosages of isavuconazole are recommended in ECMO. Echinocandins are preferred for invasive candidiasis. However, choosing echinocandins is challenging due to limited and varied data on concentration loss in the ECMO circuit. Caution is likewise advised when using liposomal amphotericin B due to uncertain concentrations and potential ECMO dysfunction based on scarce data. We further conclude with the importance of further research on the impact of ECMO on antifungal drug concentrations to optimize dosing regimens in critically ill patients.<\/jats:p>","DOI":"10.1093\/ofid\/ofae270","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T15:10:43Z","timestamp":1715181043000},"source":"Crossref","is-referenced-by-count":18,"title":["Antifungals in Patients With Extracorporeal Membrane Oxygenation: Clinical Implications"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1977-2196","authenticated-orcid":false,"given":"Lisa","family":"Kriegl","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"},{"name":"BioTechMed-Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6266-0512","authenticated-orcid":false,"given":"Stefan","family":"Hatzl","sequence":"additional","affiliation":[{"name":"BioTechMed-Graz , Graz , Austria"},{"name":"Intensive Care Unit, Department of Internal Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Schilcher","sequence":"additional","affiliation":[{"name":"Landeskrankenhaus S\u00fcdsteiermark, Wagna , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2752-1837","authenticated-orcid":false,"given":"Ines","family":"Zollner-Schwetz","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Boyer","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Geiger","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1653-2824","authenticated-orcid":false,"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"},{"name":"BioTechMed-Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Krause","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz , Graz , Austria"},{"name":"BioTechMed-Graz , Graz , Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"2024061711514679000_ofae270-B1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S2213-2600(22)00403-9","article-title":"In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study","volume":"11","author":"Lorusso","year":"2023","journal-title":"Lancet Respir Med"},{"issue":"Suppl 2","key":"2024061711514679000_ofae270-B2","first-page":"XXX\u2013XX","article-title":"229. 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