{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T17:29:36Z","timestamp":1778261376525,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Invasive fusariosis (IF) is a life-threatening opportunistic infection that affects vulnerable hosts. We conducted a multicenter and multinational retrospective study to characterize the natural history and clinical management of IF in pediatric cancer patients. We selected patients &amp;lt;18 years old who were sequentially hospitalized in 10 Latin American medical centers with a diagnosis of IF between 2002 and 2021. Data were collected using an electronic case report form complemented by a dictionary of terms. We assessed mortality rates at 30, 60, and 90 days. We collected data from 60 episodes of IF (median age, 9.8 years) that were mostly documented in patients with hematologic cancer (70%). Other risk conditions found were lymphopenia (80%), neutropenia (76.7%), and corticosteroid exposure (63.3%). IF was disseminated in 55.6% of patients. Skin lesions was present in 58.3% of our patients, followed by pulmonary involvement in 55%, sinusitis in 21.7%, bone\/joint involvement in 6.7% and 1 case each of endocarditis and brain abscess. Positive blood and skin biopsy cultures were detected in 60% and 48.3% of cases, respectively. Fusarium solani complex was the most commonly identified agent (66.6%). The majority of patients received monotherapy within the first 72 hours (71.6%), either with voriconazole or amphotericin B formulation. The mortality rates at 30, 60, and 90 days were 35%, 41.6%, and 45%, respectively. An important factor affecting mortality rates appears to be disseminated disease. The high percentage of patients with fungal involvement in multiple organs and systems highlights the need for extensive workup for additional sites of infection in severely immunocompromised children.<\/jats:p>","DOI":"10.1093\/ofid\/ofae285","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T14:57:27Z","timestamp":1715957847000},"source":"Crossref","is-referenced-by-count":5,"title":["Landscape of Invasive Fusariosis in Pediatric Cancer Patients: Results of a Multicenter Observational Study From Latin America"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7037-3425","authenticated-orcid":false,"given":"Fabianne","family":"Carlesse","sequence":"first","affiliation":[{"name":"Instituto de Oncologia Pedi\u00e1trica\u2014IOP-GRAACC-UNIFESP , Departamento de Pediatria, S\u00e3o Paulo , Brazil"},{"name":"Departamento de Pediatria, Universidade Federal de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Maria","family":"Paix\u00e3o de Sousa da Silva","sequence":"additional","affiliation":[{"name":"Instituto de Oncologia Pedi\u00e1trica\u2014IOP-GRAACC-UNIFESP , Departamento de Pediatria, S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaques","family":"Sztajnbok","sequence":"additional","affiliation":[{"name":"Instituto de Tratamento do Cancer Infantil (ITACI), Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"},{"name":"Instituto de Infectologia Emilio Ribas , Intensive Care Unit, Department of Emergency Medical Care, S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Litivinov","sequence":"additional","affiliation":[{"name":"Instituto de Tratamento do Cancer Infantil (ITACI), Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"Peron","sequence":"additional","affiliation":[{"name":"Instituto de Tratamento do Cancer Infantil (ITACI), Instituto da Crian\u00e7a do Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Hospital Infantil Darcy Vargas , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Volpe Arnoni","sequence":"additional","affiliation":[{"name":"Hospital Infantil Darcy Vargas , S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Instituto Nacional do Cancer\u2014INCA , Department of Pediatrics, Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"de Oliveira Costa","sequence":"additional","affiliation":[{"name":"Instituto Nacional do Cancer\u2014INCA , Department of Pediatrics, Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Lucia","family":"Munhoz Cavalcanti de Albuquerque","sequence":"additional","affiliation":[{"name":"Hospital Federal da Lagoa Rio de Janeiro , Department of Pediatrics, Rio de Janeiro , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Morales","sequence":"additional","affiliation":[{"name":"Hospital Erasto Gaertner , Department of Pediatrics, Curitiba , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Lopez-Medina","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica CEIP, Department of Pediatrics, Universidad del Valle, Cl\u00ednica Imbanaco, Grupo Quironsalud , Cali , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"A. Portilla","sequence":"additional","affiliation":[{"name":"Centro de Estudios en Infectolog\u00eda Pedi\u00e1trica CEIP, Department of Pediatrics, Universidad del Valle, Cl\u00ednica Imbanaco, Grupo Quironsalud , Cali , Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romina","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hospital Dr Luis Calvo Mackenna, Universidad de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Motta","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia de Porto Alegre , Department of Pediatrics, Porto Alegre , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio Ara\u00fajo","family":"Motta","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe , Curitiba , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Nobrega","family":"de Almeida Junior","sequence":"additional","affiliation":[{"name":"Departamento de Medicina- Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo-UNIFESP , S\u00e3o Paulo , Brazil"},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES) , Departamento de Medicina, UNIFESP, S\u00e3o Paulo , Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Santolaya","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hospital Dr Luis Calvo Mackenna, Universidad de Chile , Santiago , Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Lopes Colombo","sequence":"additional","affiliation":[{"name":"Departamento de Medicina- Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo-UNIFESP , S\u00e3o Paulo , Brazil"},{"name":"Antimicrobial Resistance Institute of S\u00e3o Paulo (ARIES) , Departamento de Medicina, UNIFESP, S\u00e3o Paulo , 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