{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:48:42Z","timestamp":1765889322933,"version":"3.41.2"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Early reports described an increased risk of herpes zoster following receipt of mRNA-based COVID-19 vaccines. The objective was to assess whether COVID-19 vaccine is associated with varicella-zoster virus\u2013induced neurologic disease (VZV-ND).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This multicenter retrospective case-control study with a test-negative design was conducted at 12 hospitals in Israel. We included all patients admitted with VZV-ND between January 2020 and December 2021 and matched controls with a negative polymerase chain reaction result for VZV in cerebrospinal fluid.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 188 patients meeting the case definition of VZV-ND who were admitted during the study period. Cases were matched with 376 controls. There was no significant variation in the incidence of VZV-ND between 1 year preceding and 1 year following the deployment of BNT162b2 in Israel. Analysis of persons who had received at least 1 dose of COVID-19 vaccine (n = 259) showed similar proportions of VZV-ND and non\u2013VZV-ND in 4 intervals (30, 42, 50, 60 days) following the last vaccine dose. The median time from the last vaccine dose to hospitalization with a neurologic syndrome was 53 days (IQR, 25\u2013128) and 82 days (IQR, 36\u2013132) for VZV-ND and non\u2013VZV-ND, respectively, not reaching statistical significance (P = .056). The rate of VZV-ND in vaccinated patients was no different from the rate in the unvaccinated group (30.9% vs 35.4%, P = .2).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We did not find an association between COVID-19 vaccine and VZV-ND. Since COVID-19 vaccine is now recommended yearly, every fall and winter, establishing the safety of the vaccine is of great importance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae287","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T14:19:06Z","timestamp":1716560346000},"source":"Crossref","is-referenced-by-count":2,"title":["Varicella-Zoster Virus\u2013Induced Neurologic Disease After COVID-19 Vaccination: A Multicenter Observational Cohort Study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6561-1174","authenticated-orcid":false,"given":"Meital","family":"Elbaz","sequence":"first","affiliation":[{"name":"Infectious Disease Unit, Tel Aviv Sourasky Medical Center , Tel Aviv , Israel"},{"name":"Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomer","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Sheba Medical Center , Ramat Gan , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3181-9791","authenticated-orcid":false,"given":"Dafna","family":"Yahav","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel"},{"name":"Infectious Diseases Unit, Sheba Medical Center , Ramat Gan , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Dovrat","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center , Tel-Hashomer , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nesrin","family":"Ghanem-Zoubi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Institute, Rambam Health Care Campus , Haifa , Israel"},{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1351-7135","authenticated-orcid":false,"given":"Alaa","family":"Atamna","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Rabin Medical Center, Beilinson Hospital , Petah-Tikva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Grupel","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center , Jerusalem , Israel"},{"name":"Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Reisfeld","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Haifa , Israel"},{"name":"Infectious Diseases Unit, Hillel Yaffe Medical Center , Hadera , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirit","family":"Hershman-Sarafov","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Haifa , Israel"},{"name":"Infectious Diseases Unit, Bnai Zion Medical Center , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pnina","family":"Ciobotaro","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Kaplan Medical Center , Rehovot , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronza","family":"Najjar-Debbiny","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Haifa , Israel"},{"name":"Infection Control and Prevention Unit, Lady Davis Carmel Medical Center , Haifa , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2032","authenticated-orcid":false,"given":"Tal","family":"Brosh-Nissimov","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Assuta Ashdod University Hospital , Ashdod , Israel"},{"name":"Faculty of Health Science, Ben Gurion University of the Negev , Beer Sheva , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Chazan","sequence":"additional","affiliation":[{"name":"The Ruth and Bruce Rappaport Faculty of Medicine, Technion , Haifa , Israel"},{"name":"Infectious Disease Unit, Emek Medical Center , Afula , Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Yossepowitch","sequence":"additional","affiliation":[{"name":"Infectious Disease Unit, Edith Wolfson Medical Center , Holon, Tel Aviv , 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