{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:06:50Z","timestamp":1776902810563,"version":"3.51.2"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD079695"],"award-info":[{"award-number":["R01HD079695"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Washington Royalty Research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is a global threat to infectious disease control, particularly among recently hospitalized children. We sought to determine the prevalence and mitigating factors of resistance in enteric Escherichia coli among children discharged from health facilities in western Kenya.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Between June 2016 and November 2019, children aged 1 to 59 months were enrolled at the point of discharge from the hospital. E coli was isolated by microbiological culture from rectal swabs at baseline. \u03b2-Lactamases and macrolide resistance\u2013conferring genes were detected by polymerase chain reaction. A modified Poisson regression model was used to assess the predictors mph(A) and CTX-M\u2013type extended-spectrum \u03b2-lactamase (ESBL).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 238 children whose E coli isolates were tested, 91 (38.2%) and 109 (45.8%) had detectable CTX-M\u2013type ESBL and mph(A) genes, respectively. Antibiotic treatment during hospitalization (adjusted prevalence ratio [aPR], 2.47; 95% CI, 1.12\u20135.43; P = .025), length of hospitalization (aPR, 1.42; 95% CI, 1.00\u20132.01; P = .052), and the practice of open defecation (aPR, 2.47; 95% CI, 1.40\u20134.36; P = .002) were independent predictors for CTX-M\u2013type ESBL and mph(A) genes. Pneumococcal vaccination was associated with a 43% lower likelihood of CTX-M\u2013type ESBL (aPR, 0.57; 95% CI, .38\u2013.85; P = .005), while measles vaccination was associated with a 32% lower likelihood of mph(A) genes (aPR, 0.68; 95% CI, .49\u2013.93; P = .017) in E coli isolates.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among children discharged from the hospital, history of vaccination, shorter hospital stay, lack of in-hospital antibiotic exposure, and improved sanitation were associated with a lower likelihood of AMR genes. To mitigate the continued spread of AMR, AMR control programs should consider strategies beyond antimicrobial stewardship, including improvements in sanitation, increased vaccine coverage, and the development of novel vaccines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae307","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:45:56Z","timestamp":1717447556000},"source":"Crossref","is-referenced-by-count":6,"title":["\u03b2-Lactamase and Macrolide Resistance Gene Carriage in <i>Escherichia coli<\/i> Isolates Among Children Discharged From Inpatient Care in Western Kenya: A Cross-sectional Study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-7576","authenticated-orcid":false,"given":"Polycarp","family":"Mogeni","sequence":"first","affiliation":[{"name":"Center for Microbiology Research, Kenya Medical Research Institute , Nairobi , Kenya"},{"name":"Department of Global Health, 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