{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T17:21:26Z","timestamp":1781716886108,"version":"3.54.5"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T00:00:00Z","timestamp":1717718400000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Secretaria de Estado de Sau\u0301de de Minas Gerais"},{"name":"Secretaria de Estado de Planejamento de Minas Gerais"},{"name":"Instituto Rene\u0301 Rachou"},{"DOI":"10.13039\/501100006507","name":"Fundac\u0327\u00e3o Oswaldo Cruz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Coordenac\u0327\u00e3o de Aperfeic\u0327oamento de Pessoal de N\u0131\u0301vel Superior, Brazil","award":["88882.348380"],"award-info":[{"award-number":["88882.348380"]}]},{"name":"US Collaborative Biomedical Research Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We enrolled 21 patients with laboratory-confirmed yellow fever (YF), hospitalized at Eduardo de Menezes Hospital, Brazil, to be treated with sofosbuvir, a drug approved for hepatitis C. Given the absence of specific YF antiviral treatments, the off-label nonrandomized sofosbuvir treatment aimed to address high disease severity and the risk of fatal outcomes. Patients received a daily dose of 400\u2005mg sofosbuvir from 4 to 10 days post\u2013symptom onset. YF viral load (VL) comparisons were made between treated and nontreated patients who either survived or died. The genomic VL for the treated group steadily decreased after day 7 post\u2013symptom onset, suggesting that sofosbuvir might reduce YF VL. This study underscores the urgent need for YF antiviral therapies, advocating for randomized clinical trials to further explore sofosbuvir's role in YF treatment.<\/jats:p>","DOI":"10.1093\/ofid\/ofae312","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T08:59:22Z","timestamp":1717750762000},"source":"Crossref","is-referenced-by-count":8,"title":["Sofosbuvir Off-label Treatment of Yellow Fever Patients During an Outbreak in Brazil, 2018: A Cohort Study"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-6300","authenticated-orcid":false,"given":"Izabela M","family":"Rezende","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine , Stanford, California , USA"},{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Correa","family":"Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Centre for Virus Research, Medical Research Council\/University of Glasgow , Glasgow , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais Alkifeles","family":"Costa","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Fernanda Garcia de","family":"Oliveria","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Soares","family":"Arruda","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza Parreiras","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Immunology of Viral Diseases, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Augusto","family":"Alves","sequence":"additional","affiliation":[{"name":"Immunology of Viral Diseases, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Calzavara-Silva","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Immunology, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo A","family":"Martins-Filho","sequence":"additional","affiliation":[{"name":"Integrated Group of Biomarkers Research, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[{"name":"Integrated Group of Biomarkers Research, Ren\u00e9 Rachou Institute, Oswaldo Cruz Foundation (Fiocruz) , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Antonio","family":"Bonjardim","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P","family":"Monath","sequence":"additional","affiliation":[{"name":"Crozet BioPharma LLC , Lexington, Massachusetts , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Desiree","family":"LaBeaud","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Infectious Diseases, Stanford University School of Medicine , Stanford, California , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00e2nia P","family":"Drumond","sequence":"additional","affiliation":[{"name":"Laboratory of Viruses, Microbiology Department, Biological Sciences Institute, Universidade Federal de Minas Gerais , Belo Horizonte, Minas Gerais , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Ant\u00f4nio","family":"Pascoal-Xavier","sequence":"additional","affiliation":[{"name":"Immunology of Viral Diseases, Ren\u00e9 Rachou Institute, 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