{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:13:03Z","timestamp":1789074783297,"version":"build-2803163510"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["K23 AI153390"],"award-info":[{"award-number":["K23 AI153390"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Eunice Shriver National Institute for Child Health and Human Development"},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health","award":["UL1 TR002319"],"award-info":[{"award-number":["UL1 TR002319"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Respiratory syncytial virus (RSV)\u2013associated lower respiratory tract infection contributes significantly to morbidity\/mortality worldwide in low birthweight (LBW) infants (&amp;lt;2500 g). Studies have demonstrated decreased maternal immunoglobulin G (IgG) transfer of various antibodies to LBW infants. We aimed to evaluate naturally acquired RSV anti\u2013prefusion F protein (anti-preF) antibody transfer in pregnancies with LBW versus normal birthweight (NBW) infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cohort study conducted among pregnant individuals and their infants, we tested paired maternal and singleton infant cord samples for RSV anti-preF IgG via an electrochemiluminescence immunoassay, using linear regression to evaluate associations between LBW and anti-preF IgG. Covariates included seasonality, insurance, small-for-gestational-age birthweight, and gestational age at delivery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We tested maternal\/cord RSV anti-preF IgG from 54 and 110 pregnancies with LBW and NBW infants, respectively. Of LBW infants, 22 (40.7%) were born both preterm and with small-for-gestational-age birthweight. The median (interquartile range) gestational age at delivery and birthweight were 34.0 (31.7\u201337.1) weeks and 1902 (1393\u20132276) g for LBW infants versus 39.1 (38.3\u201339.9) weeks and 3323 (3109\u20133565) g for NBW infants (both P &amp;lt; .001). In unadjusted comparisons, preterm infants had significantly lower cord anti-preF IgG levels and cord-maternal IgG ratios compared with full-term infants, while LBW infants had significantly lower cord-maternal IgG ratios than NBW infants (all P &amp;lt; .01). After adjustment for covariates, there was no difference in cord-maternal IgG ratios (\u03b2 =\u22120.29 [95% confidence interval, \u2212.63 to .05]) between LBW and NBW infants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We documented robust transfer of maternal RSV anti-preF IgG in pregnancies with both LBW and NBW infants. Further studies are needed to assess immune protection in at-risk infants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofae314","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T19:10:38Z","timestamp":1717528238000},"source":"Crossref","is-referenced-by-count":10,"title":["Transfer of Respiratory Syncytial Virus Prefusion F Protein Antibody in Low Birthweight Infants"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-5107","authenticated-orcid":false,"given":"Alisa B","family":"Kachikis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-0274","authenticated-orcid":false,"given":"Kalee","family":"Rumfelt","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan 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