{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:27:16Z","timestamp":1788474436041,"version":"build-2803163510"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["D-762-17"],"award-info":[{"award-number":["D-762-17"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2017, a mumps outbreak occurred in a US military barracks. Serum collected at service entry was used to compare pre-exposure with presumptive vaccine-induced antibody levels from persons who developed mumps (cases) and potentially exposed persons who did not develop mumps (non-cases). Sufficient information to determine levels of exposure during the outbreak was not available.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Pre-outbreak serum samples from the Department of Defense Serum Repository were available from 254 potentially exposed service members. Twelve developed clinical symptoms and had post-outbreak serum collected. All sera were tested with a mumps-specific enzyme immunoassay for immunoglobulin M, immunoglobulin G (IgG), and IgG avidity. The neutralizing antibodies to vaccine strain (Jeryl Lynn [JL], genotype A) and wildtype virus (genotype G) was assessed by a plaque reduction neutralization test. A Fisher exact test and receiver operator characteristic curve were used to analyze the antibody response for non-cases and mumps cases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Eight mumps cases were laboratory confirmed. Pre-outbreak neutralizing antibody titers to JL and genotype G mumps virus and pre-outbreak IgG index values were proportionately lower for most cases as compared with exposed non-cases. When compared with potentially exposed non-cases, cases with clinical symptoms had greater odds of having a pre-outbreak JL titer &amp;lt;41 and a genotype G titer &amp;lt;16.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We identified potential correlates of protection for mumps neutralizing antibody titers against JL and genotype G mumps viruses.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae329","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T14:16:48Z","timestamp":1718374608000},"source":"Crossref","is-referenced-by-count":10,"title":["Identifying a Level of Neutralizing Antibody That Correlates With Protection From Clinical Mumps Disease During a 2017 Mumps Outbreak Among Military Service Members"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5525-5252","authenticated-orcid":false,"given":"Sun B","family":"Sowers","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-1649","authenticated-orcid":false,"given":"Nakia S","family":"Clemmons","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3567-0381","authenticated-orcid":false,"given":"Sara","family":"Mercader","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-9504","authenticated-orcid":false,"given":"Lindsey","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brooke Army Medical Center , San Antonio, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3604-4075","authenticated-orcid":false,"given":"Heather","family":"Colley","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1832-4367","authenticated-orcid":false,"given":"Nikki N","family":"Jordan","sequence":"additional","affiliation":[{"name":"Division of Clinical Public Health and Epidemiology, Defense Centers for Public Health, Defense Health Agency\u2013Aberdeen , Edgewood, Maryland , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin C","family":"Bettger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brooke Army Medical Center , San Antonio, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3155-6058","authenticated-orcid":false,"given":"Nina B","family":"Masters","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4473-3902","authenticated-orcid":false,"given":"Ana E","family":"Markelz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Brooke Army Medical Center , San Antonio, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-8151","authenticated-orcid":false,"given":"Carole J","family":"Hickman","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention , Atlanta, Georgia , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"2024072916040328500_ofae329-B1","volume-title":"Epidemiology and prevention of vaccine-preventable diseases.","author":"Atkinson","year":"2007","edition":"10th ed"},{"key":"2024072916040328500_ofae329-B2","volume-title":"Plotkin\u2019s vaccines","author":"Plotkin","year":"2023","edition":"8th 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Morbidity and mortality weekly report"},{"key":"2024072916040328500_ofae329-B9","doi-asserted-by":"crossref","article-title":"A Brief description of the operation of the DoD serum repository","author":"Perdue","DOI":"10.7205\/MILMED-D-14-00739"},{"key":"2024072916040328500_ofae329-B10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1128\/JVI.06125-11","article-title":"Recent mumps outbreaks in vaccinated populations: no evidence of immune escape","volume":"86","author":"Rubin","year":"2012","journal-title":"J Virol"},{"key":"2024072916040328500_ofae329-B11","doi-asserted-by":"crossref","first-page":"e00320-18","DOI":"10.1128\/mSphere.00320-18","article-title":"Development and use of an endpoint titration assay to characterize mumps IgG avidity following measles, mumps, and rubella vaccination and wild-type mumps 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