{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T17:06:06Z","timestamp":1755795966702,"version":"3.41.2"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T00:00:00Z","timestamp":1720742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technological Project of Ningbo City","award":["2022S032"],"award-info":[{"award-number":["2022S032"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Anncaliia algerae, a microsporidium, has risen to prominence as an opportunistic pathogen, particularly afflicting individuals who are immunocompromised with conditions such as rheumatoid arthritis, organ transplantation, and hematologic malignancy. Surprisingly, despite its recognized impact, the identification of A algerae in ascitic fluid has not been documented. As such, we pinpointed A algerae as the probable instigator of ascitic accumulation in a patient with a history of acute myeloid leukemia and extended periods of immunosuppressive therapy. For this patient, there were no signs of A algerae\u2013related infections (eg, myositis), vocal cord involvement, or disseminated infection. The presence of A algerae was finally identified by next-generation metagenomic sequencing analysis of the ascitic fluid. Clinical presentation was characterized by elevated C-reactive protein levels (110.7 mg\/L), diminished platelet count (48 \u00d7 109\/L), abdominal distension secondary to ascitic fluid accumulation, and lower limb pain, and it showed marked improvement following a 4-day regimen of sulfamethoxazole\/trimethoprim and albendazole. Despite this promising response, the patient succumbed to aspiration of vomitus. This case underscores the importance of considering rarer organisms, such as A algerae infection, in patients who are immunocompromised and present with unexplained ascites accumulation. It highlights the potential effectiveness of sulfamethoxazole\/trimethoprim and albendazole in managing such cases. Further research is warranted to elucidate optimal management strategies and improve outcomes in similar clinical scenarios.<\/jats:p>","DOI":"10.1093\/ofid\/ofae393","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T17:29:08Z","timestamp":1720805348000},"source":"Crossref","is-referenced-by-count":1,"title":["Identification of <i>Anncaliia algerae<\/i> in Ascites in an Immunosuppressed Patient, China"],"prefix":"10.1093","volume":"11","author":[{"given":"Zanzan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Ningbo University , Ningbo , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Co, Ltd , Hangzhou , China"},{"name":"Hangzhou DA Medical Laboratory , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Lu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Dian Diagnostics Group Co, Ltd , Hangzhou , China"},{"name":"Hangzhou DA Medical Laboratory , Hangzhou , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Ningbo University , Ningbo , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Ningbo University , Ningbo , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongcheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Ningbo University , Ningbo , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,12]]},"reference":[{"key":"2024082915055488800_ofae393-B1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1111\/j.1550-7408.2010.00510.x","article-title":"Human vocal cord infection with the microsporidium","volume":"57","author":"Cali","year":"2010","journal-title":"J Eukaryot Microbiol"},{"key":"2024082915055488800_ofae393-B2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/01.qco.0000244055.46382.23","article-title":"Microsporidiosis: current status","volume":"19","author":"Didier","year":"2006","journal-title":"Curr Opin Infect Dis"},{"key":"2024082915055488800_ofae393-B3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1056\/NEJMoa032655","article-title":"Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen","volume":"351","author":"Coyle","year":"2004","journal-title":"N 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