{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T02:06:09Z","timestamp":1781143569799,"version":"3.54.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["FIS PI21\/01640"],"award-info":[{"award-number":["FIS PI21\/01640"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["ICI21\/00103"],"award-info":[{"award-number":["ICI21\/00103"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["JR20\/00012"],"award-info":[{"award-number":["JR20\/00012"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["PI21\/00498"],"award-info":[{"award-number":["PI21\/00498"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["2017SGR00792"],"award-info":[{"award-number":["2017SGR00792"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Spanish Ministry of Health","award":["ICI19\/00025"],"award-info":[{"award-number":["ICI19\/00025"]}]},{"name":"Spanish Ministry of Health","award":["PI22\/00647"],"award-info":[{"award-number":["PI22\/00647"]}]},{"name":"Spanish Ministry of Health","award":["RD21\/0017\/0009"],"award-info":[{"award-number":["RD21\/0017\/0009"]}]},{"name":"Spanish Ministry of Health","award":["RD21\/0017\/0019"],"award-info":[{"award-number":["RD21\/0017\/0019"]}]},{"name":"Red de Terapia Celular TerCel","award":["RD16\/0011\/0005"],"award-info":[{"award-number":["RD16\/0011\/0005"]}]},{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["CP042702\/LCF\/PR\/GN18\/50310007"],"award-info":[{"award-number":["CP042702\/LCF\/PR\/GN18\/50310007"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Asociaci\u00f3n Espa\u00f1ola Contra el Cancer","award":["LABAE21971FERN"],"award-info":[{"award-number":["LABAE21971FERN"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This study aimed to describe documented infections associated with postinfusion fever after CAR T-cell therapy and to evaluate daily changes in vital signs, laboratory results, and the National Early Warning Score (NEWS) in patients with and without confirmed bacterial infections following fever onset, with the objective of assisting in antibiotic stewardship.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a retrospective, observational study including all consecutive adult patients who received CAR T-cell therapy. Documented infection in the first fever episode after infusion, and clinical and analytic trend comparison of patients with bacterial documented infections and those without documented infections, are described.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 152 patients treated with CAR T-cell therapy, 87 (57.2%) had fever within 30 days of infusion, with a median time from infusion to fever of 3 (interquartile range, 2\u20135) days. Of these 87 patients, 82 (94.3%) received broad-spectrum antibiotics. Infection was documented in 9 (10.3%) patients and only 4 (4.6%) had bacterial infections. Clinical signs and biomarkers were similar in patients with bacterial documented infection and in those without documented infection at fever onset. Fever, tachycardia, and high C-reactive protein levels remained high during the first 3 days after CAR T-cell infusion, even when no infection was documented.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Fever is a common symptom following CAR T-cell infusion and is largely treated with broad-spectrum antibiotics. However, confirmed bacterial documented infections after the first fever post\u2013CAR T-cell infusion are very unusual. Because clinical parameters and biomarkers are not useful for identifying infectious fever, other methods should be assessed to ensure the proper use of antibiotics.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae398","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T12:24:44Z","timestamp":1720700684000},"source":"Crossref","is-referenced-by-count":7,"title":["Chimeric Antigen Receptor T-Cell Postinfusion Fever: Infection Profile, Clinical Parameters, and Biomarkers Trends to Assist Antibiotic Stewardship"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6831-0054","authenticated-orcid":false,"given":"Olivier","family":"Peyrony","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona , Barcelona , Spain"},{"name":"Emergency Department, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Garcia-Pouton","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Chumbita","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Teijon-Lumbreras","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso Francesco","family":"Aiello","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Monz\u00f3-Gallo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Gallardo-Pizarro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , 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Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Fernandez de Larrea","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Mensa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital Clinic of Barcelona, Instituto de Investigaciones Biom\u00e9dicas August Pi i Sunyer, University of Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2490-0217","authenticated-orcid":false,"given":"Pedro","family":"Puerta-Alcalde","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, 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