{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:14:41Z","timestamp":1792458881646,"version":"4.5.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The aim of this study was to assess the epidemiology, clinical manifestations, and outcome of mucormycosis over 15 years in a single center in France.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective analysis of all mucormycosis cases in our institution from 1 January 2006 to 31 December 2020 and analyzed patients\u2019 medical records, laboratory results, and treatment to describe the epidemiology, clinical manifestations, diagnosis, treatment, and outcome. Mucorales quantitative polymerase chain reaction (qPCR) for the diagnosis was implemented in 2015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-seven mucormycosis cases were analyzed in 77 patients, with a median age of 54 years (60% male). Identified risk factors were hematological diseases (46 cases [60%]), solid malignancies (2 cases), solid organ transplants (3), burns (18), diabetes only (7), and trauma (1). Sites of infection were lungs (42%), sinus (36%), skin (31%), central nervous system (9%), liver (8%), others (6%), and disseminated (12%). Diagnosis remained difficult and qPCR contributed to mucormycosis diagnosis in 30% of cases. Among hematology patients, serum qPCR was the only positive test in 15% of cases. A mixed mold infection was diagnosed in 24 of 77 (31%) patients. Surgical treatment was undertaken in 43 (56%) cases. Most patients received liposomal amphotericin B (89%), with a combination therapy in 18 of 77 cases (23%). Three-month survival rate was 40% (95% confidence interval [CI], .30\u2013.53]). As for treatment, adjunction of surgery (hazard ratio, 0.47 [95%CI, .25\u2013.91); P = 0.02) was associated with lower mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Mucormycosis remained associated with high mortality, especially in the hematological and burn populations. Surgery in combination with antifungal treatment was associated with improved survival.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae426","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T18:38:54Z","timestamp":1721673534000},"source":"Crossref","is-referenced-by-count":4,"title":["Epidemiology, Clinical Manifestations, Treatment, and Outcome of Mucormycosis: A Review of 77 Cases From a Single Center in France"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-2601","authenticated-orcid":false,"given":"Blandine","family":"Denis","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu","family":"Resche-Rigon","sequence":"additional","affiliation":[{"name":"Department of Biomedical Statistics and Methodology, H\u00f4pital Saint-Louis, Fernand Widal, Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Raffoux","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Hematology, H\u00f4pital Saint-Louis, Fernand Widal, Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Ronchetti","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Saint-Louis, Fernand Widal, Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-4889","authenticated-orcid":false,"given":"Emmanuel","family":"Dudoignon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Burn Intensive Care Unit, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Verillaud","sequence":"additional","affiliation":[{"name":"Department of Head and Neck surgery, H\u00f4pital Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris, Inserm U1131, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Valade","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, H\u00f4pital Saint-Louis, Fernand Widal, Lariboisi\u00e8re, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwena\u00ebl","family":"Lorillon","sequence":"additional","affiliation":[{"name":"Department of Pneumology, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Rabian","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2013Teenagers and Young Adults Unit, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali\u00e9nor","family":"Xhaard","sequence":"additional","affiliation":[{"name":"Service d\u2019hematologie\u2013greffes, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Touratier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Hamane","sequence":"additional","affiliation":[{"name":"Laboratoire de parasitologie-mycologie, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Alanio","sequence":"additional","affiliation":[{"name":"Laboratoire de parasitologie-mycologie, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"D\u00e9partement de mycologie, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Centre National de R\u00e9f\u00e9rence Mycoses Invasives et Antifongiques, Groupe de recherche Mycologie Translationnelle Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-1097","authenticated-orcid":false,"given":"Nathalie","family":"De Castro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, H\u00f4pital Saint-Louis, Assistance Publique\u2013H\u00f4pitaux de Paris , Paris ,","place":["France"]},{"name":"Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"2024092717554744400_ofae426-B1","article-title":"Mucormycosis in hematopoietic cell transplant recipients and in patients with hematological malignancies in the era of new antifungal agents","volume":"8","author":"Miller","year":"2020","journal-title":"Open Forum Infect 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