{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T12:45:15Z","timestamp":1780058715917,"version":"3.54.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T00:00:00Z","timestamp":1723248000000},"content-version":"vor","delay-in-days":11,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"NICHD","doi-asserted-by":"publisher","award":["R61HD105618"],"award-info":[{"award-number":["R61HD105618"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVID-19 from March 2020 to May 2023 across age strata at 5 US sites participating in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence consortium. Eligible patients had an upper respiratory swab that tested positive for severe acute respiratory syndrome coronavirus 2 by nucleic acid amplification. Adjusted odds ratios (aOR) of clinical outcomes were determined for children versus adults, for pediatric age strata compared to adolescents (12\u201317 years), and for adult age strata compared to young adults (22\u201349 years).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 9101 patients in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence cohort, 1560 were hospitalized for COVID-19 as the primary reason. Compared to adults (22\u2013105 years, n = 675), children (0\u201321 years, n = 885) were less commonly vaccinated (14.3% vs 34.5%), more commonly infected with the Omicron variant (49.5% vs 26.1%) and had fewer comorbidities (P &amp;lt; .001 for most comparisons), except for lung disease (P = .24). After adjusting for confounding variables, children had significantly lower odds of receiving supplemental oxygen (aOR, 0.57; 95% confidence interval, .35\u2013.92) and death (aOR, 0.011; 95% confidence interval, &amp;lt;.01\u2013.58) compa\u00ad\u00adred to adults. Among pediatric age strata, adolescents 12\u201317 years had the highest odds of receiving supplemental oxygen, high-flow oxygen, and ICU admission. Among adults, those 50\u201364 years had the highest odds of mechanical ventilation and ICU admission.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Clinical outcomes of COVID-19 differed across pediatric and adult age strata. Adolescents experienced the most severe disease among children, whereas adults 50\u201364 years experienced the most severe disease among adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae443","type":"journal-article","created":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T13:55:33Z","timestamp":1723298133000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical Features and Outcomes of Pediatric and Adult Patients Hospitalized for Coronavirus Disease 2019: A Comparison Across Age Strata"],"prefix":"10.1093","volume":"11","author":[{"given":"Grace X","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, GA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Gopchandani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, GA , 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Mien","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, GA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Oseguera","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"},{"name":"Department of Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abiodun","family":"Foresythe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"},{"name":"Department of Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanchita","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Bakar Computational Health Sciences Institute, University of California , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venice","family":"Servellita","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"},{"name":"Department of Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Sotomayor Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Infectious Diseases, University of California at San Francisco , San Francisco, CA , 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Grady Memorial Health Center , Atlanta, GA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0524-9473","authenticated-orcid":false,"given":"Jennifer","family":"Dien Bard","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles , Los Angeles, CA , USA"},{"name":"Keck School of Medicine, University of Southern California , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Ying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles , Los Angeles, CA , USA"},{"name":"Keck School of Medicine, University of Southern California , Los Angeles, CA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Flores-Vazquez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory 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