{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:30:44Z","timestamp":1787009444592,"version":"build-2736575974"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T00:00:00Z","timestamp":1722902400000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with pulmonary tuberculosis (PTB) are contagious, particularly to their household contacts. Their infectivity has been associated with the bacterial load in sputum samples. This study investigated if the bacterial load in sputum samples as quantified by Xpert MTB\/RIF and Xpert Ultra is correlated with the extent that latent tuberculosis infection (LTBI) occurred in household contacts of people with PTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was performed including people with PTB presenting at Vall d\u2019Hebron University Hospital, Barcelona, between 2011 and 2021. Their infection ratio, representing the proportion of household members found with LTBI in contact tracing investigation, was compared with the quantitative results of Xpert MTB\/RIF and Xpert Ultra using ordinal regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 107 people with PTB were included. Among their 398 household contacts, 126 (31.7%) cases of LTBI and 14 cases with active TB disease (3.5%) were reported. Higher bacterial load in Xpert MTB\/RIF and Xpert Ultra baseline sputum was significantly associated with increased infection ratios, providing better estimates than conventional acid-fast bacilli (AFB) smear grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Xpert MTB\/RIF and Xpert Ultra could serve as an alternative to AFB sputum-smear grading in determining contact tracing priorities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofae450","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T17:58:45Z","timestamp":1722621525000},"source":"Crossref","is-referenced-by-count":4,"title":["Usefulness of Xpert MTB\/RIF and Xpert Ultra to Categorize Risk of Tuberculosis Transmission to Household Contacts"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3840-2008","authenticated-orcid":false,"given":"Alexander","family":"Mol","sequence":"first","affiliation":[{"name":"International Health Unit Vall D\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2194-5447","authenticated-orcid":false,"given":"Adri\u00e1n","family":"S\u00e1nchez-Montalv\u00e1","sequence":"additional","affiliation":[{"name":"International Health Unit Vall D\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona , Spain"},{"name":"Grupo de Estudio de Infecciones por Micobacterias, Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica , Madrid , Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network, Instituto de Salud Carlos III , Madrid , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7238-8337","authenticated-orcid":false,"given":"Juan","family":"Espinosa-Pereiro","sequence":"additional","affiliation":[{"name":"International Health Unit Vall D\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona , Spain"},{"name":"Grupo de Estudio de Infecciones por Micobacterias, Sociedad Espa\u00f1ola de Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica , Madrid , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9223-7790","authenticated-orcid":false,"given":"Maria 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau","family":"Bosch-Nicolau","sequence":"additional","affiliation":[{"name":"International Health Unit Vall D\u2019Hebron-Drassanes, Infectious Diseases Department, Vall d\u2019Hebron University Hospital, PROSICS Barcelona , Barcelona , Spain"},{"name":"Center for Biomedical Research in Infectious Diseases Network, Instituto de Salud Carlos III , Madrid , Spain"},{"name":"Department of Medicine, Universitat Aut\u00f2noma de Barcelona , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Luiza","family":"de Souza-Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Vall d\u2019Hebron University Hospital , Barcelona , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Vall d\u2019Hebron University Hospital , 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