{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:30:58Z","timestamp":1791232258402,"version":"4.1.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["RS-2023-00219002"],"award-info":[{"award-number":["RS-2023-00219002"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Health, Republic of Korea","award":["2020-ER5304-02"],"award-info":[{"award-number":["2020-ER5304-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne disease caused by Bandavirus dabieense (SFTS virus [SFTSV]). Recently, at least 6 different genotypes of SFTSV have been identified, with genotypes A, D, and F dominant in China and B dominant in Japan and Korea. This study investigated the effect of SFTSV genotypes circulating in South Korea on disease severity, viral load, and cytokine profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We prospectively enrolled 70 patients with SFTS from July 2015 to June 2022. Serial plasma samples were obtained during hospitalization and analyzed. Viral load was measured by real-time reverse-transcription polymerase chain reaction. Partial sequences of the viral genome were analyzed for genotyping. Plasma concentrations of 17 cytokines were measured by multiplex-bead immunoassay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 70 samples, 51 could be genotyped. Genotype B was predominant (80.4%) and other genotypes were uncommon. Intensive care unit admission rates (51.2% vs 50.0%) and mortality rates (26.8% vs 40.0%) did not show any significant differences between genotype B and non-B genotypes. The initial viral load did not show any significant differences (3.59 vs 3.64 log copies\/\u03bcL), whereas viral load measured at hospital day 3\u20134 tended to be higher in genotype B than non-B genotypes (3.83 vs 1.83 log copies\/\u03bcL, P = .07). Additionally, the plasma concentrations of interferon-\u03b1, interleukin 10, and interferon-\u03b3\u2013induced protein 10, which are closely related to mortality in cases of SFTS, did not show any significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SFTSV genotype B was the prevalent genotype in South Korea, with no genotype-specific difference in clinical outcomes, initial viral load, or cytokine profiles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofae508","type":"journal-article","created":{"date-parts":[[2024,9,18]],"date-time":"2024-09-18T23:25:54Z","timestamp":1726701954000},"source":"Crossref","is-referenced-by-count":11,"title":["Effect of Severe Fever With Thrombocytopenia Syndrome Virus Genotype on Disease Severity, Viral Load, and Cytokines in South Korea"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6945-6100","authenticated-orcid":false,"given":"Ji-Soo","family":"Kwon","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Yeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choi Young","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Yeon","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woori","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2075-4497","authenticated-orcid":false,"given":"Taeeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine , Jinju ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4538-7371","authenticated-orcid":false,"given":"Se Yoon","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Chung-Ang University Hospital , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Yeon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Dongguk University Ilsan Hospital , Goyang ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye Hee","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Mu","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-3185","authenticated-orcid":false,"given":"Yong Pil","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Infectious 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of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-8253","authenticated-orcid":false,"given":"Sung-Han","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine , Seoul ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"2024092714521695200_ofae508-B1","doi-asserted-by":"crossref","first-page":"19563","DOI":"10.1038\/srep19563","article-title":"Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean","volume":"6","author":"Fu","year":"2016","journal-title":"Sci Rep"},{"key":"2024092714521695200_ofae508-B2","first-page":"597","article-title":"Genotype analysis of severe fever with thrombocytopenia syndrome virus 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