{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:10:23Z","timestamp":1785355823769,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Australasian College of Dermatology"},{"DOI":"10.13039\/100014555","name":"Murdoch Children's Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Scabies and impetigo cause direct health effects and contribute to severe infectious and immune-mediated complications. Ivermectin-based mass drug administration can reduce scabies and impetigo prevalence in island settings with high prevalence, but the effectiveness in moderate-prevalence settings is not known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a single-arm, before\u2013after community intervention trial. Mass drug administration was offered to the entire population of 4 villages in Uttarakhand, India. The treatment consisted of 2 doses, given 7 days apart, of oral ivermectin (\u223c200 \u03bcg\/kg), or topical 5% permethrin if ivermectin was contraindicated. The primary outcome was the prevalence of scabies at 12 months compared with baseline, as diagnosed using clinical assessment and the 2020 International Alliance for the Control of Scabies criteria. Secondary outcomes included the prevalence of impetigo at each time point. The trial was registered with the Australian and New Zealand Trials Registry (ACTRN12619001712190).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In January 2020, 1211 participants were enrolled (100% of the estimated village population). Treatment coverage was high\u20141204 (99.4%) and 1177 (97.2%) received 1 and 2 doses, respectively. Scabies was diagnosed in 91 participants (7.5%) and impetigo in 15 (1.2%). In February 2021, 1190 (98.3% of baseline) participants re-enrolled, and of these 11 had scabies (0.9%; relative risk reduction, 87.7%; 95% CI, 77.1%\u201393.4%) and 5 had impetigo (0.4%; relative risk reduction, 66.1%; 95% CI, 7.0%\u201387.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A single round of ivermectin-based mass drug administration substantially reduced the prevalence of scabies and impetigo in this setting with moderate scabies prevalence in northern India.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae573","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T11:59:23Z","timestamp":1727783963000},"source":"Crossref","is-referenced-by-count":3,"title":["Ivermectin-Based Mass Drug Administration for Scabies in Northern India: A Single-Arm Community Intervention Trial"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-1287","authenticated-orcid":false,"given":"Daniel","family":"Engelman","sequence":"first","affiliation":[{"name":"Tropical Diseases Research Group, Murdoch Children's Research Institute , Melbourne, Victoria ,","place":["Australia"]},{"name":"Department of Paediatrics, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Melbourne Children's Global Health, Royal Children's Hospital , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Singh","sequence":"additional","affiliation":[{"name":"Garhwal Community Development and Welfare Society , Chamba, Uttarakhand ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah J","family":"Woodall","sequence":"additional","affiliation":[{"name":"Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Tropical Diseases Research Group, Murdoch Children's Research Institute , Melbourne, Victoria ,","place":["Australia"]},{"name":"Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj Kumari","family":"Singh","sequence":"additional","affiliation":[{"name":"Garhwal Community Development and Welfare Society , Chamba, Uttarakhand ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Tropical Diseases Research Group, Murdoch Children's Research Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anneke C","family":"Grobler","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Clinical Epidemiology & Biostatistics Unit, Murdoch Children's Research Institute , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Herbertpur Christian Hospital , Dehradun, Uttarakhand ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C","family":"Steer","sequence":"additional","affiliation":[{"name":"Tropical Diseases Research Group, Murdoch Children's Research Institute , Melbourne, Victoria ,","place":["Australia"]},{"name":"Department of Paediatrics, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Melbourne Children's Global Health, Royal Children's Hospital , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Grills","sequence":"additional","affiliation":[{"name":"Nossal Institute for Global Health, School of Population and Global Health, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]},{"name":"Australia India Institute, University of Melbourne , Melbourne, Victoria ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"2024102921301857400_ofae573-B1","doi-asserted-by":"crossref","first-page":"e2167","DOI":"10.1371\/journal.pntd.0002167","article-title":"Toward the global control of human scabies: introducing the International Alliance for the Control of Scabies","volume":"7","author":"Engelman","year":"2013","journal-title":"PLoS Negl 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