{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:30Z","timestamp":1792512870669,"version":"4.5.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009139","name":"DZIF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006443","name":"Center for Infectious Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is limited evidence on point-of-care ultrasound for tuberculosis (TB), but studies suggest high sensitivity, especially for lung ultrasound (LUS). However, insufficient data are available on specificity of the examination and its generalizability to a broader patient population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Our study aimed to establish accuracy for lung, chest, and abdominal ultrasound, individually and in combination, for TB diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a prospective diagnostic accuracy study among consecutive adult out- and inpatients with probable TB in three German referral hospitals. We applied a comprehensive standardized ultrasound protocol. TB diagnosis was established by a microbiological reference standard including polymerase chain reaction and culture.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 102 participants originating from 30 different countries were enrolled. HIV prevalence was 7\/99 (7%) and 73\/102 (72%) had confirmed TB. TB was limited to the lungs in 15\/34 (44%) of refugees and 27\/39 (69%) in nonrefugees. Focused assessment with sonography for HIV-associated tuberculosis had a sensitivity of 40% (95% confidence interval [CI], 30\u201352) and specificity of 55% (95% CI, 38\u201372). Additional findings, such as small subpleural consolidations on LUS had a high sensitivity (88%; 95% CI, 78\u201393), but a low specificity (17%; 95% CI, 8\u201335). Larger consolidations in the lung apices had a sensitivity of 19% (95% CI, 12\u201330) and a specificity of 97% (95% CI, 83\u2013100).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study establishes the first data on LUS performance against a comprehensive reference standard. Overall, our data suggest that ultrasound does not meet the requirements for triage but previously described and novel ultrasound targets in combination could aid in the clinical decision making.<\/jats:p>\n                  <jats:p>Registry: DRKS00026636<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae651","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:52:38Z","timestamp":1733878358000},"source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic Accuracy of Lung and Abdominal Ultrasound for Tuberculosis in a German Multicenter Cohort of Patients With Presumed Tuberculosis Disease"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2139-737X","authenticated-orcid":false,"given":"Stefan Fabian","family":"Weber","sequence":"first","affiliation":[{"name":"Department for Infectious Disease and Tropical Medicine, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]},{"name":"Department for Parasitology, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]},{"name":"German Center for Infectious Disease Research, DZIF Partner Site Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[{"name":"Department for Pneumology and Critical Care Medicine, Thoraxklinik Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-4668","authenticated-orcid":false,"given":"Nils","family":"Wetzstein","sequence":"additional","affiliation":[{"name":"Department 2 of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University Frankfurt , Frankfurt am Main 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\u00a0","place":["Germany"]},{"name":"German Center for Infectious Disease Research, DZIF Partner Site Cologne , Cologne ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"G\u00fcttlein","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Tobian","sequence":"additional","affiliation":[{"name":"Department for Infectious Disease and Tropical Medicine, University Hospital Heidelberg , Heidelberg ,","place":["Germany"]},{"name":"German Center for Infectious Disease Research, DZIF 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