{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:46:27Z","timestamp":1775011587071,"version":"3.50.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Institute of Health Information and Statistics"},{"DOI":"10.13039\/501100017021","name":"Systemic Risk Institute","doi-asserted-by":"publisher","award":["LX22NPO5101"],"award-info":[{"award-number":["LX22NPO5101"]}],"id":[{"id":"10.13039\/501100017021","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union - Next Generation EU"},{"DOI":"10.13039\/100009122","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009122","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We examined the clinical effectiveness of molnupiravir in reducing deaths in a real-world cohort of adult patients with COVID-19 during the Omicron outbreak.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a population-wide retrospective cohort study in the Czech Republic. We analyzed all 74 541 patients with an officially registered diagnosis of SARS-CoV-2 infection between 1 January and 31 December 2022, aged 18 years or older, treated with molnupiravir. The primary outcome was 30-day all-cause mortality; the secondary outcome was 30-day COVID-19-related mortality. Hazard ratios (HRs) were estimated using stratified Cox regression and the Fine-Gray model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The use of molnupiravir in adult SARS-CoV-2 positive patients was associated with a lower risk of both 30-day all-cause mortality: adjusted HR 0.58 (95% confidence interval, 0.53\u20130.64; P &amp;lt; .001) and 30-day COVID-19\u2013related mortality: adjusted HR 0.50 (95% confidence interval, 0.42\u20130.58; P &amp;lt; .001). The effect of molnupiravir was highly significant regardless of sex, Deyo-Charlson Comorbidity Index score, hospitalization status, COVID-19 vaccination status, and patients older than age 65 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In this cohort study, early initiation of molnupiravir was associated with a significant reduction in 30-day all-cause and COVID-19\u2013related mortality in adult SARS-CoV-2 positive patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae685","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:33:01Z","timestamp":1732033981000},"source":"Crossref","is-referenced-by-count":2,"title":["Real Clinical Effectiveness of Molnupiravir Against 30-day Mortality Among 74 541 SARS-CoV-2\u2013Positive Patients: A Nationwide Cohort Study From the Czech Republic"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7166-032X","authenticated-orcid":false,"given":"Tom\u00e1\u0161","family":"Pavl\u00edk","sequence":"first","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Jarkovsk\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"\u0160anca","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0424-9941","authenticated-orcid":false,"given":"Martina","family":"Koziar Va\u0161\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer University Hospital , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Dlouh\u00fd","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Masaryk Hospital in \u00dast\u00ed and Labem , \u00dast\u00ed and Labem ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0834-7650","authenticated-orcid":false,"given":"Vladim\u00edr","family":"\u010cern\u00fd","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Resuscitation and Intensive Medicine, Charles University in Prague, Faculty of Medicine in Hradec Kr\u00e1lov\u00e9 , Hradec Kr\u00e1lov\u00e9 ,","place":["Czech Republic"]},{"name":"Department of Anaesthesia and Intensive Care Medicine, Charles University in Prague, 3rd Faculty of Medicine , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"\u0160toura\u010d","sequence":"additional","affiliation":[{"name":"Department of Simulation Medicine, Faculty of Medicine, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"Department of Paediatric Anaesthesiology and Intensive Care Medicine, University Hospital Brno and Medical Faculty of Masaryk University , Brno ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlastimil","family":"V\u00e1lek","sequence":"additional","affiliation":[{"name":"Minister of Health, Ministry of Health of the Czech Republic , Prague ,","place":["Czech Republic"]},{"name":"Department of Radiology and Nuclear Medicine, University Hospital Brno and Medical Faculty of Masaryk University , Prague ,","place":["Czech Republic"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladislav","family":"Du\u0161ek","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University , Brno ,","place":["Czech Republic"]},{"name":"Department of Data Analysis, Institute of Health Information and Statistics of the Czech Republic , Prague ,","place":["Czech 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