{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:49:33Z","timestamp":1789411773491,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Clinical Research Plan","award":["SHDC12024115"],"award-info":[{"award-number":["SHDC12024115"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tuberculous meningitis (TBM) can lead to ophthalmic nerve palsy (ONP), a severe neurological complication. This study aims to evaluates the incidence and risk factors for ONP in TBM patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This retrospective study included 250 TBM patients from the Shanghai Public Health Clinical Center (2013-2022). Clinical and imaging data were analyzed, with logistic regression identifying risk factors for ONP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ONP occurred in 6.8% (17\/250) of TBM patients. Those with ONP had higher intracranial pressure (ICP) (257.69 \u00b1 68.12 mmH2O vs 191.65 \u00b1 91.58 mmH2O; P = 0.012), cerebrospinal fluid protein levels, and a higher prevalence of tuberculomas (29.4% vs 10.7%; P = 0.039). Logistic regression identified pre-treatment ICP, CD4 percentage, and tuberculomas as significant risk factors. Linezolid use was a protective factor for ONP recovery.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Six point eight percent (17\/250) of patients with TBM developed ONP as a complication. ICP, CD4 counts, and tuberculomas are key predictors. Linezolid shows potential as a therapeutic agent for improving outcomes in TBM patients with neurological complications, warranting further study.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae686","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T11:49:50Z","timestamp":1732016990000},"source":"Crossref","is-referenced-by-count":3,"title":["Incidence and Risk Factors of Ophthalmic Nerve Palsy in Patients With Tuberculous Meningitis: A Retrospective Study and Literature Review"],"prefix":"10.1093","volume":"11","author":[{"given":"Zhen-Tao","family":"Fei","sequence":"first","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xia","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]},{"name":"School of Medicine, Fudan University , Shanghai ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanghai Public Health Clinical Center, Fudan University , Shanghai ,","place":["China"]},{"name":"School of Medicine, Southern University of Science and Technology , Shenzhen ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"2024122308171775600_ofae686-B1","author":"World Health Organization"},{"key":"2024122308171775600_ofae686-B2","first-page":"783","article-title":"Optic nerve involvement in tuberculous meningitis","volume":"22","author":"Kalra","year":"1985","journal-title":"Indian Pediatr"},{"key":"2024122308171775600_ofae686-B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0022-510X(95)00334-X","article-title":"Prognosis of tuberculous meningitis: a multivariate analysis","volume":"137","author":"Misra","year":"1996","journal-title":"J Neurol Sci"},{"key":"2024122308171775600_ofae686-B4","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0002-9394(56)91768-8","article-title":"Some ocular sequelae of tuberculous meningitis; 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