{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:03:40Z","timestamp":1784563420182,"version":"3.55.0"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Women's Reproductive Health Research"},{"name":"Eunice Shriver National Institute for Child Health and Human Development","award":["2 K12HD001264-21"],"award-info":[{"award-number":["2 K12HD001264-21"]}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National"},{"name":"Center for Advancing Translational Sciences of the National Institutes of Health","award":["UL1 TR002319"],"award-info":[{"award-number":["UL1 TR002319"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Immunization against influenza and respiratory syncytial virus (RSV) protects pregnant individuals and their infants against infection via transplacental transport of immunoglobulin G (IgG). We sought to evaluate the quantity and efficiency of maternal influenza- and RSV-specific IgG transfer in pregnancies with preterm and full-term deliveries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Delivery samples from 115 maternal-infant pairs (2018-2021) were analyzed for RSV prefusion F and IAV-H3 and IAV-H1 antibodies using electrochemiluminescence assays. We used Wilcoxon rank sum tests, t tests, Pearson correlation coefficients (PCCs), and linear regression to evaluate distributions of IgG results by maternal influenza vaccination status and preterm birth (&amp;lt;37 weeks).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Approximately 70% of pregnant persons received influenza vaccine. Maternal and cord antibody concentrations were highest in the influenza-vaccinated group for IAV-H3 and IAV-H1 regardless of preterm birth status (maternal H3, P = .004; cord H3, P = .03; maternal H1, P = .0001; cord H1, P = .0002). Preterm infants had significantly lower cord to maternal IgG transfer ratios for IAV-H3 and RSV when compared with full-term infants (P \u2264 .05). Correlations between maternal and cord IgG concentrations were significant (P \u2264 .001) for all 3 viruses, with the strongest correlation for H3 (PCC: IAV-H3, 0.77; IAV-H1, 0.68; RSV, 0.62). Associations between maternal IgG transfer and preterm birth were significant for IAV-H3 and RSV (IAV-H3, \u03b2 = \u22120.42; RSV, \u03b2 = \u22120.63; P \u2264 .05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Maternal antibody following vaccination or infection is readily transferred across the placenta. Preterm infants have higher influenza IgG following maternal influenza vaccination and are at highest risk of lower IgG transfer ratios without vaccination.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae723","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T08:59:46Z","timestamp":1735549186000},"source":"Crossref","is-referenced-by-count":11,"title":["Maternal-Infant Respiratory Syncytial Virus and Influenza A Virus Antibody Transfer in Preterm and Full-term Infants"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5128-0274","authenticated-orcid":false,"given":"Kalee E","family":"Rumfelt","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Michigan , Ann Arbor, Michigan ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-868X","authenticated-orcid":false,"given":"Mindy","family":"Pike","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E","family":"Stolarczuk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2745-7638","authenticated-orcid":false,"given":"Ava","family":"Lekander","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2906-8335","authenticated-orcid":false,"given":"Adam S","family":"Lauring","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Michigan , Ann Arbor, Michigan ,","place":["USA"]},{"name":"Department of Microbiology and Immunology, University of Michigan , Ann Arbor, Michigan ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1357-8405","authenticated-orcid":false,"given":"Linda O","family":"Eckert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington ,","place":["USA"]},{"name":"Department of Global Health, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-4178","authenticated-orcid":false,"given":"Janet A","family":"Englund","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seattle Children's Hospital Research Institute , Seattle, Washington ,","place":["USA"]},{"name":"Department of Pediatrics, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-8895","authenticated-orcid":false,"given":"Emily T","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Michigan , Ann Arbor, Michigan ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0358-5107","authenticated-orcid":false,"given":"Alisa B","family":"Kachikis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Washington , Seattle, Washington ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"2025013005292511400_ofae723-B1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/S0140-6736(22)00478-0","article-title":"Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis","volume":"399","author":"Li","year":"2022","journal-title":"Lancet"},{"key":"2025013005292511400_ofae723-B2","doi-asserted-by":"crossref","first-page":"e497","DOI":"10.1016\/S2214-109X(19)30545-5","article-title":"Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study","volume":"8","author":"Wang","year":"2020","journal-title":"Lancet Glob Health"},{"key":"2025013005292511400_ofae723-B3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S2213-2600(18)30496-X","article-title":"Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017","volume":"7","author":"GBD 2017 Influenza Collaborators","year":"2019","journal-title":"Lancet Respir Med"},{"key":"2025013005292511400_ofae723-B4","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1001\/jama.2021.7776","article-title":"Realizing the potential of maternal influenza vaccination","volume":"325","author":"Azziz-Baumgartner","year":"2021","journal-title":"JAMA"},{"key":"2025013005292511400_ofae723-B5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/cei.13234","article-title":"The impact of timing of maternal influenza immunization on infant antibody levels at birth","volume":"195","author":"Zhong","year":"2019","journal-title":"Clin Exp Immunol"},{"key":"2025013005292511400_ofae723-B6","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S2213-2600(19)30479-5","article-title":"Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials","volume":"8","author":"Omer","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2025013005292511400_ofae723-B7","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1080\/21645515.2021.1955608","article-title":"Maternal RSV vaccine development: where to from here?","volume":"17","author":"Gunatilaka","year":"2021","journal-title":"Hum Vaccin Immunother"},{"key":"2025013005292511400_ofae723-B8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10995-019-02844-y","article-title":"Influenza vaccine efficacy and effectiveness in pregnant women: systematic review and meta-analysis","volume":"24","author":"Quach","year":"2020","journal-title":"Matern Child Health J"},{"key":"2025013005292511400_ofae723-B9","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/21645515.2017.1345385","article-title":"Influenza vaccination during pregnancy for prevention of influenza confirmed illness in the infants: a systematic review and meta-analysis","volume":"14","author":"Nunes","year":"2018","journal-title":"Hum Vaccin Immunother"},{"key":"2025013005292511400_ofae723-B10","author":"Centers for Disease Control and Prevention"},{"key":"2025013005292511400_ofae723-B11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1080\/14760584.2021.1915138","article-title":"Efficacy and safety of influenza vaccination during pregnancy: realizing the potential of maternal influenza immunization","volume":"20","author":"Regan","year":"2021","journal-title":"Expert Rev Vaccines"},{"key":"2025013005292511400_ofae723-B12","doi-asserted-by":"crossref","first-page":"e214","DOI":"10.1542\/peds.2009-0913","article-title":"New intrauterine growth curves based on United States data","volume":"125","author":"Olsen","year":"2010","journal-title":"Pediatrics"},{"key":"2025013005292511400_ofae723-B13","doi-asserted-by":"crossref","first-page":"e2352387","DOI":"10.1001\/jamanetworkopen.2023.52387","article-title":"Timing of maternal COVID-19 vaccine and antibody concentrations in infants born preterm","volume":"7","author":"Kachikis","year":"2024","journal-title":"JAMA Netw Open"},{"key":"2025013005292511400_ofae723-B14","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1097\/AOG.0000000000003892","article-title":"Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222","volume":"135","author":"American College of Obstetricians and Gynecologists","year":"2020","journal-title":"Obstet Gynecol"},{"key":"2025013005292511400_ofae723-B15","author":"World Health Organization"},{"key":"2025013005292511400_ofae723-B16","author":"MSD"},{"key":"2025013005292511400_ofae723-B17","author":"SAS Institute Inc"},{"key":"2025013005292511400_ofae723-B18","author":"Equator Network"},{"key":"2025013005292511400_ofae723-B19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/jpids\/piaa040","article-title":"Transplacental respiratory syncytial virus and influenza virus antibody transfer in Alaska Native and Seattle mother-infant pairs","volume":"10","author":"Chu","year":"2021","journal-title":"J Pediatr Infect Dis Soc"},{"key":"2025013005292511400_ofae723-B20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.earlhumdev.2010.11.003","article-title":"Transplacental transport of IgG antibodies to preterm infants: a review of the literature","volume":"87","author":"van den Berg","year":"2011","journal-title":"Early Hum Dev"},{"key":"2025013005292511400_ofae723-B21","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.vaccine.2020.12.049","article-title":"Infant immunity against viral infections is advanced by the placenta-dependent vertical transfer of maternal antibodies","volume":"40","author":"Albrecht","year":"2022","journal-title":"Vaccine"},{"key":"2025013005292511400_ofae723-B22","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1002\/jmv.27383","article-title":"Transplacental transfer of RSV antibody in Australian First Nations infants","volume":"94","author":"Homaira","year":"2022","journal-title":"J Med Virol"},{"key":"2025013005292511400_ofae723-B23","doi-asserted-by":"crossref","first-page":"e0153019","DOI":"10.1371\/journal.pone.0153019","article-title":"Development of electrochemiluminescent serology assays to measure the humoral response to antigens of respiratory syncytial virus","volume":"11","author":"Maifeld","year":"2016","journal-title":"PLoS One"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofae723\/61294430\/ofae723.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/1\/ofae723\/61294430\/ofae723.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/1\/ofae723\/61294430\/ofae723.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:29:47Z","timestamp":1738214987000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofae723\/7934619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,23]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,23]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofae723","relation":{},"ISSN":["2328-8957"],"issn-type":[{"value":"2328-8957","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,12,23]]},"article-number":"ofae723"}}