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We present the case of a 70-year-old Indian woman newly diagnosed with AIDS and pancreatic tuberculosis with miliary disseminated disease. Her clinical course was complicated by IRIS related to HIV-TB coinfection despite sequential and targeted anti-infective therapies. We review the presentation, pathophysiology, and risk factors for developing IRIS with HIV and pancreatic TB.<\/jats:p>","DOI":"10.1093\/ofid\/ofae746","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T13:05:48Z","timestamp":1734786348000},"source":"Crossref","is-referenced-by-count":2,"title":["Disseminated TB With IRIS Presenting as a Pancreatic Mass in Newly Diagnosed HIV: A Case Report"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4947-240X","authenticated-orcid":false,"given":"Nina","family":"Akbar","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Nuvance Health\/Norwalk Hospital , Norwalk, Connecticut ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Mariuz","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, University of Rochester Medical Center , Rochester, New York 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