{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:49:35Z","timestamp":1787165375229,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031003","name":"CDC","doi-asserted-by":"publisher","award":["75D30120P09851"],"award-info":[{"award-number":["75D30120P09851"]}],"id":[{"id":"10.13039\/100031003","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031003","name":"CDC","doi-asserted-by":"publisher","award":["75D30122C14640"],"award-info":[{"award-number":["75D30122C14640"]}],"id":[{"id":"10.13039\/100031003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lyme disease is the most common vector-borne disease in the United States; however, its frequency is not reliably measured through surveillance. Electronic health records (EHR) might capture the frequency and characteristics of Lyme disease cases more accurately. We queried EHR from 1 health system to describe the epidemiology of Lyme disease cases in Wisconsin during 2016\u20132019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Within a cohort of persons evaluated for Lyme disease, we applied a Lyme disease case definition based on first-line antibiotics within 14 days of a Lyme disease diagnosis code or test order or on the same day as a related keyword in clinical notes. We compared characteristics of cases to those of cases reported through surveillance and reviewed medical charts to assess case definition validity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 67 289 possible Lyme disease events in the cohort, 13 494 (20.1%) met our Lyme disease case definition. Cases were more common among males, children 5\u20139 years, older adults, White non-Hispanic persons, and in the summer months. EHR-based Lyme disease incidence was 4\u20138 times that reported through surveillance. The EHR definition had moderately high sensitivity (83.4%) and specificity (71.1%) for confirmed and probable Lyme disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EHR queries show promise to capture the incidence of Lyme disease more completely and provide more robust clinical information than public health surveillance. Demographic and seasonal characteristics of EHR-identified cases were comparable to those identified through surveillance. Further algorithm refinement might improve accuracy of measuring Lyme disease in EHR systems.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/ofid\/ofae758","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T23:23:33Z","timestamp":1736205813000},"source":"Crossref","is-referenced-by-count":7,"title":["Epidemiology of Lyme Disease as Identified Through Electronic Health Records in a Large Midwestern Health System, 2016\u20132019"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-6688","authenticated-orcid":false,"given":"Kiersten J","family":"Kugeler","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention, Division of Vector-Borne Diseases , Fort Collins, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Scotty","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute, Marshfield Clinic Health System , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison F","family":"Hinckley","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Division of Vector-Borne Diseases , Fort Collins, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A","family":"Hook","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Division of Vector-Borne Diseases , Fort Collins, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney C","family":"Nawrocki","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Division of Vector-Borne Diseases , Fort Collins, Colorado ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Nikolai","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute, Marshfield Clinic Health System , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7551-4810","authenticated-orcid":false,"given":"Alexandra M","family":"Linz","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute, Marshfield Clinic Health System , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Meece","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute, Marshfield Clinic Health System , Marshfield, Wisconsin ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M","family":"Schotthoefer","sequence":"additional","affiliation":[{"name":"Marshfield Clinic Research Institute, Marshfield Clinic Health System , Marshfield, Wisconsin 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