{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:11:39Z","timestamp":1753877499259,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T00:00:00Z","timestamp":1736121600000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1169555"],"award-info":[{"award-number":["OPP1169555"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-13-JSV1-0004","grant 2013"],"award-info":[{"award-number":["ANR-13-JSV1-0004","grant 2013"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation Simone Beer"},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00074147","grant 2017"],"award-info":[{"award-number":["00074147","grant 2017"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Val\u00e9rie Briand"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Malaria infections in pregnancy are a major cause of maternal morbidity and neonatal mortality in sub-Saharan Africa. A high proportion of these infections are submicroscopic, which are usually asymptomatic and therefore untreated during pregnancy. Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) aims to prevent and treat all potential infections whether submicroscopic or not. However, the resistance of parasites to SP is steadily increasing. The dynamic of microscopic and submicroscopic infections in a cohort of Beninese women throughout their pregnancy and its relation to IPTp-SP has been assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>As a subsample of the RECIPAL project, 130 women with at least 2 infections detected by polymerase chain reaction during their pregnancy were included. Infections were categorized as new (isolated) or persistent based on msp-2 genotyping, where persistent infections had identical genotypes in all studied time points. Submicroscopic infections were defined as polymerase chain reaction\u2013positive and thick blood smear\u2013negative. The persistence of infections according to IPTp-SP uptake was assessed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 73.1% of women (95 women of 130) had exclusively persistent infections throughout their pregnancy, whereas only 7.7% (10 of 130) had exclusively new infections. During pregnancy, the median time spent with 1 persistent infection was 7.2 weeks. A considerable proportion of these persistent infections 64.3% (72 of 113) was only submicroscopic. Approximately 20% of these persistent infections occurred despite the use of IPTp-SP.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Using new antimalarial combinations could contribute to limit the persistence of submicroscopic infections and their probable negative effects on the mother and the fetus.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofae762","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T15:45:54Z","timestamp":1736178354000},"source":"Crossref","is-referenced-by-count":0,"title":["Dynamics of Persistent Submicroscopic and Microscopic <i>Plasmodium falciparum<\/i> in Pregnant Women Under Intermittent Preventive Treatment: A Study Cohort in Benin"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8424-332X","authenticated-orcid":false,"given":"Sayeh","family":"Jafari-Guemouri","sequence":"first","affiliation":[{"name":"UMR261 MERIT, Universit\u00e9 Paris Cit\u00e9, IRD , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robinson","family":"D\u00e9gb\u00e8gni","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Benin (IRCB) , Abomey-Calavi ,","place":["Benin"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Courtois","sequence":"additional","affiliation":[{"name":"Genetics Department, Institut Curie, PSL Research University , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Accrombessi","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Benin (IRCB) , Abomey-Calavi ,","place":["Benin"]},{"name":"Faculty of Infectious and Tropical Diseases, Disease Control Department, London School of Hygiene and Tropical Medicine , London, Royaume-Uni"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Massougbodji","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Benin (IRCB) , Abomey-Calavi ,","place":["Benin"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8409-3678","authenticated-orcid":false,"given":"Xavier C","family":"Ding","sequence":"additional","affiliation":[{"name":"Abbott Rapid Diagnostics , Baar ,","place":["Switzerland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicaise Tuikue","family":"Ndam","sequence":"additional","affiliation":[{"name":"UMR261 MERIT, Universit\u00e9 Paris Cit\u00e9, IRD , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atika","family":"Mama","sequence":"additional","affiliation":[{"name":"Clinical Research Institute of Benin (IRCB) , Abomey-Calavi ,","place":["Benin"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Fievet","sequence":"additional","affiliation":[{"name":"UMR261 MERIT, Universit\u00e9 Paris Cit\u00e9, IRD , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Sarrasin-Hubert","sequence":"additional","affiliation":[{"name":"Centre National de R\u00e9f\u00e9rence du Paludisme , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Cottrell","sequence":"additional","affiliation":[{"name":"UMR261 MERIT, Universit\u00e9 Paris Cit\u00e9, IRD , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vale\u0301rie","family":"Briand","sequence":"additional","affiliation":[{"name":"UMR261 MERIT, Universit\u00e9 Paris Cit\u00e9, IRD , Paris ,","place":["France"]},{"name":"Epicentre , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,6]]},"reference":[{"volume-title":"World malaria report 2023","year":"2023","author":"World Health Organization","key":"2025021312030104300_ofae762-B1"},{"key":"2025021312030104300_ofae762-B2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.4269\/ajtmh.2004.71.35","article-title":"The contribution of malaria in pregnancy to perinatal mortality","volume":"71","author":"van Geertruyden","year":"2004","journal-title":"Am J Trop Med 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