{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:16:02Z","timestamp":1759529762030,"version":"3.41.2"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["5UM1AI069501-19"],"award-info":[{"award-number":["5UM1AI069501-19"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Roe Green Center for Travel Medicine and Global Health\/University Hospitals Cleveland Medical Center","award":["J0713"],"award-info":[{"award-number":["J0713"]}]},{"name":"University Hospitals Minority Faculty Career Development Award"},{"name":"University Hospitals Cleveland Medical Center","award":["P0603"],"award-info":[{"award-number":["P0603"]}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["K01AI166126"],"award-info":[{"award-number":["K01AI166126"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>There is conflicting evidence regarding the impact of chronic hepatitis B virus (HBV) on SARS-CoV-2 outcomes. Additionally, the impact of SARS-CoV-2 vaccination and variant periods on outcomes in HBV\/SARS-CoV-2 coinfection remain unexplored.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We utilized the TriNetX database to compare adults with HBV\/SARS-CoV-2 (vs SARS-CoV-2 alone) across 97 US healthcare systems from 2020 to 2023. We assessed the odds of all inpatient hospitalizations, intensive care unit admissions, mechanical ventilation, 30-day, 90-day, and overall mortality. In sensitivity analyses, we excluded HIV, hepatitis C virus, and transplant cases and stratified the HBV\/SARS-CoV-2 cohort by cirrhosis status. We applied propensity score matching to address confounding and reported odds ratios (OR) with 95% confidence intervals (CI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 4 206 774 individuals with SARS-CoV-2, about 0.2% (8293) were HBV\/SARS-CoV-2. Individuals with HBV\/SARS-CoV-2 (vs SARS-CoV-2 alone) had higher odds of intensive care unit admissions (OR, 1.18; 95% CI, 1.02\u20131.36), 90-day (OR, 1.22; 95% CI, 1.01\u20131.41) and overall mortality (OR, 1.18; 95% CI, 1.06\u20131.33). In sensitivity analyses, those with HBV\/SARS-CoV-2 and cirrhosis had a 2.0- to 2.50-fold higher odds of adverse outcomes. Notably, even individuals with HBV\/SARS-CoV-2 without cirrhosis had higher odds of mortality. Vaccinated (vs unvaccinated) individuals with HBV\/SARS-CoV-2 had 57%, 54%, and 29% reduction in 30-day, 90-day, and overall mortality, respectively. The pre-Delta variant period was associated with higher odds of hospitalization compared to the Omicron but not the Delta period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Chronic HBV was associated with worse SARS-CoV-2 outcomes, whereas SARS-CoV-2 vaccination reduced the likelihood of adverse outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf013","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T09:05:23Z","timestamp":1736499923000},"source":"Crossref","is-referenced-by-count":1,"title":["Chronic Hepatitis B and COVID-19 Clinical Outcomes in the United States: A Multisite Retrospective Cohort Study"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8474-1812","authenticated-orcid":false,"given":"George A","family":"Yendewa","sequence":"first","affiliation":[{"name":"Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]},{"name":"Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center , Cleveland, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Temitope","family":"Olasehinde","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center , Cleveland, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4831-1185","authenticated-orcid":false,"given":"Frank","family":"Mulindwa","sequence":"additional","affiliation":[{"name":"Department of Medicine, United Health Services Wilson Medical Center , Johnson City, New York ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Salata","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University School of Medicine , Cleveland, Ohio ,","place":["USA"]},{"name":"Division of Infectious Diseases and HIV Medicine, University Hospitals Cleveland Medical Center , Cleveland, Ohio ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-6154","authenticated-orcid":false,"given":"Amir M","family":"Mohareb","sequence":"additional","affiliation":[{"name":"Center for Global Health, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts ,","place":["USA"]},{"name":"Department of Medicine, Harvard Medical School , Boston, Massachusetts ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Case Western Reserve University School of Medicine , 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