{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:11:42Z","timestamp":1753877502369,"version":"3.41.2"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI121990"],"award-info":[{"award-number":["R21AI121990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Fund","award":["K01HL140285","U54CA272205","K24AI11499","R01HL130750","R01HL146377"],"award-info":[{"award-number":["K01HL140285","U54CA272205","K24AI11499","R01HL130750","R01HL146377"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>While sulfadoxine-pyrimethamine has been the primary drug in intermittent preventive treatment in pregnancy, dihydroartemisinin-piperaquine (DP) is being considered as an alternative. DP may lead to lower antimalarial antibodies in the mother, resulting in higher risk of malaria in infancy. We probed cord blood sera collected from women enrolled in a clinical trial of sulfadoxine-pyrimethamine vs DP on a protein microarray containing diverse Plasmodium falciparum erythrocyte membrane proteins 1 to measure the impact of intermittent preventive treatment in pregnancy on proteins associated with malaria disease susceptibility. These results suggest that effective maternal malaria prevention may not alter the susceptibility of infants to malaria.<\/jats:p>","DOI":"10.1093\/ofid\/ofaf037","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T18:04:44Z","timestamp":1737655484000},"source":"Crossref","is-referenced-by-count":0,"title":["Choice of Drug for Malaria Prevention During Pregnancy Does Not Affect Infant Serologic Responses to <i>Plasmodium falciparum<\/i> Erythrocyte Membrane Proteins 1"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1964-7130","authenticated-orcid":false,"given":"Amed","family":"Ouattara","sequence":"first","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana R","family":"Andronescu","sequence":"additional","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Adams","sequence":"additional","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankur","family":"Sharma","sequence":"additional","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6026-3342","authenticated-orcid":false,"given":"Rie","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine , Irvine, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-0097","authenticated-orcid":false,"given":"Aarti","family":"Jain","sequence":"additional","affiliation":[{"name":"Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine , Irvine, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omid","family":"Taghavian","sequence":"additional","affiliation":[{"name":"Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine , Irvine, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Algis","family":"Jasinskas","sequence":"additional","affiliation":[{"name":"Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine , Irvine, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip L","family":"Felgner","sequence":"additional","affiliation":[{"name":"Vaccine Research and Development Center, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine , Irvine, California ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don P","family":"Mathanga","sequence":"additional","affiliation":[{"name":"Malaria Alert Center, Kamuzu University of Health Sciences , Blantyre ,","place":["Malawi"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jobiba","family":"Chinkhumba","sequence":"additional","affiliation":[{"name":"Malaria Alert Center, Kamuzu University of Health Sciences , Blantyre ,","place":["Malawi"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-9593","authenticated-orcid":false,"given":"Miriam K","family":"Laufer","sequence":"additional","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A","family":"Travassos","sequence":"additional","affiliation":[{"name":"Malaria Research Program, Center for Vaccine Development and Global Heath, School of Medicine, University of Maryland , Baltimore, Maryland ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"volume-title":"WHO policy brief for the implementation of intermittent preventive treatment of malaria in pregnancy using sulfadoxine-pyrimethamine (IPTp-SP)","year":"2014","author":"World Health Organization","key":"2025021717222250800_ofaf037-B1"},{"key":"2025021717222250800_ofaf037-B2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ijgo.12835","article-title":"A systematic review and meta-analysis of dihydroartemisinin-piperaquine versus sulphadoxine-pyrimethamine for malaria prevention in pregnancy","volume":"146","author":"Olaleye","year":"2019","journal-title":"Int J Gynaecol Obstet"},{"key":"2025021717222250800_ofaf037-B3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1509150","article-title":"Dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy","volume":"374","author":"Kakuru","year":"2016","journal-title":"N Engl J Med"},{"key":"2025021717222250800_ofaf037-B4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0031182015001626","article-title":"Plasmodium malaria and antimalarial antibodies in the first year of life","volume":"143","author":"Dobbs","year":"2016","journal-title":"Parasitology"},{"key":"2025021717222250800_ofaf037-B5","doi-asserted-by":"crossref","first-page":"e0026823","DOI":"10.1128\/iai.00268-23","article-title":"Associations between prenatal malaria exposure, maternal antibodies at birth, and malaria susceptibility during the first year of life in Burkina Faso","volume":"91","author":"Natama","year":"2023","journal-title":"Infect Immun"},{"key":"2025021717222250800_ofaf037-B6","doi-asserted-by":"crossref","first-page":"E1791","DOI":"10.1073\/pnas.1120455109","article-title":"Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children","volume":"109","author":"Lavstsen","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025021717222250800_ofaf037-B7","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1086\/503776","article-title":"Virulence of malaria is associated with differential expression of Plasmodium falciparum var gene subgroups in a case-control study","volume":"193","author":"Kaestli","year":"2006","journal-title":"J Infect Dis"},{"key":"2025021717222250800_ofaf037-B8","doi-asserted-by":"crossref","first-page":"e14741","DOI":"10.1371\/journal.pone.0014741","article-title":"Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome","volume":"6","author":"Ochola","year":"2011","journal-title":"PLoS One"},{"key":"2025021717222250800_ofaf037-B9","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1038\/s41598-018-24462-4","article-title":"Children with cerebral malaria or severe malarial anaemia lack immunity to distinct variant surface antigen subsets","volume":"8","author":"Travassos","year":"2018","journal-title":"Sci Rep"},{"key":"2025021717222250800_ofaf037-B10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/infdis\/jiab351","article-title":"The effect of intermittent preventive treatment of malaria during pregnancy and placental malaria on infant risk of malaria","volume":"225","author":"Andronescu","year":"2022","journal-title":"J Infect Dis"},{"key":"2025021717222250800_ofaf037-B11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/978-1-0716-2189-9_25","article-title":"Protein microarrays as a tool to analyze antibody responses to variant surface antigens expressed on the surface of Plasmodium falciparum\u2013infected erythrocytes","volume":"2470","author":"Zhou","year":"2022","journal-title":"Methods Mol Biol"},{"key":"2025021717222250800_ofaf037-B12","doi-asserted-by":"crossref","first-page":"14401","DOI":"10.1038\/s41598-021-92974-7","article-title":"Malian adults maintain serologic responses to virulent PfEMP1s amid seasonal patterns of fluctuation","volume":"11","author":"Ventimiglia","year":"2021","journal-title":"Sci Rep"},{"key":"2025021717222250800_ofaf037-B13","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.4269\/ajtmh.14-0524","article-title":"Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravid, malaria-exposed Malian women","volume":"92","author":"Travassos","year":"2015","journal-title":"Am J Trop Med Hyg"},{"key":"2025021717222250800_ofaf037-B14","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1093\/infdis\/jiaa043","article-title":"Dynamics of PfEMP1 antibody profile from birth to 12 months of age in Beninese infants","volume":"221","author":"Moussiliou","year":"2020","journal-title":"J Infect Dis"},{"key":"2025021717222250800_ofaf037-B15","doi-asserted-by":"crossref","first-page":"e137262","DOI":"10.1172\/jci.insight.137262","article-title":"Longitudinal analysis of naturally acquired PfEMP1 CIDR domain variant antibodies identifies associations with malaria protection","volume":"5","author":"Obeng-Adjei","year":"2020","journal-title":"JCI Insight"},{"key":"2025021717222250800_ofaf037-B16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.chom.2019.10.012","article-title":"Protective immunity against severe malaria in children is associated with a limited repertoire of antibodies to conserved PfEMP1 variants","volume":"26","author":"Tessema","year":"2019","journal-title":"Cell Host Microbe"},{"key":"2025021717222250800_ofaf037-B17","doi-asserted-by":"crossref","first-page":"5967","DOI":"10.1128\/IAI.00327-07","article-title":"Characterization of the antibody response against Plasmodium falciparum erythrocyte membrane protein 1 in human volunteers","volume":"75","author":"Krause","year":"2007","journal-title":"Infect Immun"}],"container-title":["Open Forum Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/ofid\/advance-article-pdf\/doi\/10.1093\/ofid\/ofaf037\/61591808\/ofaf037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/2\/ofaf037\/61591808\/ofaf037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/ofid\/article-pdf\/12\/2\/ofaf037\/61591808\/ofaf037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T17:23:12Z","timestamp":1739812992000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ofid\/article\/doi\/10.1093\/ofid\/ofaf037\/7976928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,23]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,31]]}},"URL":"https:\/\/doi.org\/10.1093\/ofid\/ofaf037","relation":{},"ISSN":["2328-8957"],"issn-type":[{"type":"electronic","value":"2328-8957"}],"subject":[],"published-other":{"date-parts":[[2025,2]]},"published":{"date-parts":[[2025,1,23]]},"article-number":"ofaf037"}}