{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:58:11Z","timestamp":1790009891614,"version":"4.0.1"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD081929"],"award-info":[{"award-number":["R01HD081929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"US National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI162235"],"award-info":[{"award-number":["R01AI162235"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Maternal HIV infection can affect placental immunology and expression of the neonatal crystallizable fragment receptor (FcRn), which allows transplacental antibody transfer. This study delineated differences in placental FcRn and T-cell expression by HIV status, with or without viral suppression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This observational cohort study in Pune, India, followed pregnant women with and without HIV through 1 year postpartum; 42 had placenta collected, stratified by HIV status. FcRn expression was analyzed by Western blot (normalized by GADPH) and compared using ImageJ. Placental CD4\/CD8 abundance was assessed by immunofluorescent counting per high powered field.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median gestational age at delivery was 38.3 weeks (interquartile range [IQR] 37.5\u201339.1). Of 18 women living with HIV, all were on combined antiretroviral therapy with a median CD4 of 455 cells\/mm3 (IQR 281\u2013640) at entry and 429 cells\/mm3 (IQR 317\u2013686) at delivery. Ten had undetectable virus (\u226440 copies\/mL); of those with detectable virus, the median viral load was 151 copies\/mL (IQR 118.15\u2013539 334). Relative placental FcRn expression was lower in women living with HIV compared to without (median 0.54 vs 0.84, P = .01) and not associated with CD4 or viral load. Women with HIV had significantly higher abundance of placental CD8+ T cells, regardless of viral suppression, compared to women without.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Maternal HIV, even with viral suppression, is associated with lower placental FcRn expression and increased placental CD8+ T cells. These results suggest that dysregulation may not be completely reversed by antiretroviral therapy and could contribute to poorer infant outcomes, even in the absence of mother-to-child HIV transmission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf047","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T18:05:46Z","timestamp":1738346746000},"source":"Crossref","is-referenced-by-count":4,"title":["HIV-related Differences in Placental Immunology: Data From the PRACHITi Cohort in Pune, India"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9487-7775","authenticated-orcid":false,"given":"Jyoti S","family":"Mathad","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine , Center for Global Health, Department of Medicine, New York, New York 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