{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:43:27Z","timestamp":1792010607723,"version":"4.4.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Myroides species, Gram-negative bacilli from the Flavobacteriaceae family, are typically considered low-virulence pathogens but have previously been described as extensively drug-resistant. This study investigates the clinical features and outcomes of Myroides infections.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective cohort study of patients hospitalized at Cleveland Clinic with Myroides infection. Infections were defined as a positive Myroides culture from a sterile site that were treated with an antibiotic to which the isolate was susceptible. Controls were hospitalized patients with a positive culture for Myroides, who did not meet the definition for infection. Survival for infected patients and uninfected controls was compared using Cox proportional hazards regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Between January 2015 and September 2023, 52 positive Myroides species cultures were identified, with 21 deemed infections. A higher proportion of Myroides-infected patients than controls had diabetes mellitus. The most common infections were skin\/soft-tissue infections (42.8%), osteomyelitis (33.3%), and urinary tract infections (19%); and 28.5% were bacteremic infections. All isolates were resistant to aminoglycosides, but the majority were susceptible to trimethoprim-sulfamethoxazole (81%), ciprofloxacin (57%), and meropenem (68%). The main antimicrobial treatments provided were meropenem, ciprofloxacin, and trimethoprim-sulfamethoxazole. A significant difference in survival was not found between patients with Myroides infection and uninfected controls (hazard ratio, 3.42; 95% confidence interval, .63\u201318.74; P = .16).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>All patients in this study had reasonable treatment options, belying previous reports of extensive antibiotic resistance in Myroides. Our small study did not detect a statistically significant decrease in survival among Myroides-infected patients compared to controls.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/ofid\/ofaf049","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T16:29:51Z","timestamp":1738081791000},"source":"Crossref","is-referenced-by-count":7,"title":["Clinical Features and Outcomes of <i>Myroides<\/i> Species Infections"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0547-2384","authenticated-orcid":false,"given":"Mayyadah H","family":"Alabdely","sequence":"first","affiliation":[{"name":"Infectious Disease Department, Cleveland Clinic , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Englund","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Cleveland Clinic , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6766-9874","authenticated-orcid":false,"given":"Nabin K","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Infectious Disease Department, Cleveland Clinic , Cleveland, Ohio ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,28]]},"reference":[{"key":"2025021717220194500_ofaf049-B1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.idcr.2017.02.012","article-title":"Myroides bacteremia: a case report and concise review","volume":"8","author":"Beharrysingh","year":"2017","journal-title":"IDCases"},{"key":"2025021717220194500_ofaf049-B2","author":"Hoste"},{"key":"2025021717220194500_ofaf049-B3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/jcp.32.1.73","article-title":"Flavobacterium odoratum: a species resistant to a wide range of antimicrobial agents","volume":"32","author":"Holmes","year":"1979","journal-title":"J Clin Pathol"},{"key":"2025021717220194500_ofaf049-B4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s15010-010-0077-1","article-title":"Septic shock, pneumonia, and soft tissue infection due to Myroides odoratimimus: report of a case and review of Myroides infections","volume":"39","author":"Benedetti","year":"2011","journal-title":"Infection"},{"key":"2025021717220194500_ofaf049-B5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jhin.2011.09.010","article-title":"Nosocomial outbreak of Myroides odoratimimus urinary tract infection in a Tunisian hospital","volume":"80","author":"Ktari","year":"2012","journal-title":"J Hosp Infect"},{"key":"2025021717220194500_ofaf049-B6","first-page":"342","article-title":"Myroides odoratimimus bacteremia in a diabetic patient","volume":"28","author":"Endicott-Yazdani","year":"2015","journal-title":"Proc (Bayl Univ Med Cent)"},{"key":"2025021717220194500_ofaf049-B7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13756-018-0391-4","article-title":"Myroides odoratimimus urinary tract infection in an immunocompromised patient: an emerging multidrug-resistant micro-organism","volume":"7","author":"Lorenzin","year":"2018","journal-title":"Antimicrob Resist Infect Control"},{"key":"2025021717220194500_ofaf049-B8","doi-asserted-by":"crossref","first-page":"acmi000549.v2","DOI":"10.1099\/acmi.0.000549.v2","article-title":"A case series and literature review of infections due to Myroides spp.: identification of contributing factors and emerging antibiotic susceptibility trends","volume":"5","author":"Khan","year":"2023","journal-title":"Access Microbiol"},{"key":"2025021717220194500_ofaf049-B9","first-page":"6422861","article-title":"Extensively drug-resistant Myroides odoratus in critically ill patients: a case series and literature review","volume":"2022","author":"O\u2019Neal","year":"2022","journal-title":"Case Rep Infect Dis"},{"key":"2025021717220194500_ofaf049-B10","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.3389\/fmicb.2017.02591","article-title":"Myroides odoratimimus forms structurally complex and inherently antibiotic-resistant biofilm in a wound-like in vitro model","volume":"8","author":"Pompilio","year":"2017","journal-title":"Front Microbiol"},{"key":"2025021717220194500_ofaf049-B11","volume-title":"CLSI Publishes M100\u2014performance standards for antimicrobial susceptibility testing","edition":"33rd edition"},{"key":"2025021717220194500_ofaf049-B12","author":"R Core Team","year":"2024"},{"key":"2025021717220194500_ofaf049-B13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s100960070001","article-title":"Molecular typing of Myroides odoratimimus (Flavobacterium odoratum) urinary tract infections in a Turkish hospital","volume":"19","author":"Ya\u011fci","year":"2000","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2025021717220194500_ofaf049-B14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41426-018-0061-x","article-title":"Whole-genome sequencing of a large collection of Myroides odoratimimus and Myroides odoratus isolates and antimicrobial susceptibility studies","volume":"7","author":"Gunzer","year":"2018","journal-title":"Emerg Microbes Infect"}],"container-title":["Open Forum Infectious 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